Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 13/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | GCK | P35557 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.44 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11069813 | 0.85 | ADORA2B (0.44) | ADORA2BADORA2AADORA1ABL1ADORA3 | |
| SCHEMBL11065275 | 0.83 | ADORA2B (0.45) | ADORA2BADORA2AADORA1ABL1GCK | |
| SCHEMBL11066718 | 0.81 | ADORA2B (0.44) | ADORA2BADORA2AADORA1ABL1GCK | |
| SCHEMBL11069532 | 0.80 | SMN1; SMN2 (0.51) | ADORA2BADORA2AADORA1ADORA3ALDH1A1 | |
| SCHEMBL11069278 | 0.80 | ADORA2B (0.43) | ADORA2BADORA2AADORA1ABL1GCK | |
| SCHEMBL11071690 | 0.79 | ADORA2B (0.42) | ADORA2BADORA2AADORA1ABL1GCK | |
| SCHEMBL11070623 | 0.79 | ADORA2B (0.42) | ADORA2BADORA2AADORA1ABL1GCK | |
| SCHEMBL11694093 | 0.75 | POLB (0.64) | ABL1GCKALDH1A1POLB | |
| SCHEMBL11063569 | 0.74 | PDE3B (0.42) | ADORA2BADORA2AADORA1ADORA3CYP46A1 | |
| SCHEMBL7056328 | 0.72 | CDK5 (0.68) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448780-A | N-(Lower-alkyl)-N'-[5-(pyridinyl)-2-pyridinyl]ureas and cardiotonic use thereof | STERLING DRUG INC. (US) | 1984-05-15 | — | — | US | claimed |
| US-4448780-A | N-(Lower-alkyl)-N'-[5-(pyridinyl)-2-pyridinyl]ureas and cardiotonic use thereof | STERLING DRUG INC. (US) | 1984-05-15 | — | — | US | disclosed |