Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.73 |
| ▸ | BLM | P54132 | 1/20 | 0.73 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.73 |
| ▸ | LDHA | P00338 | 1/20 | 0.54 |
| ▸ | LDHB | P07195 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL28860992 | 1.00 | LMNA (0.73) | LMNAALOX15BLMPMP22LDHA | |
| Oxalic Acid SCHEMBL27599458 | 1.00 | LMNA (0.73) | LMNAALOX15BLMPMP22LDHA | |
| Acetic Acid SCHEMBL27827411 | 0.86 | LMNA (0.80) | LMNAALOX15BLMPMP22LDHA | |
| Acetamide SCHEMBL27626974 | 0.86 | — | — | |
| Acetic Acid SCHEMBL1715034 | 0.86 | — | — | |
| Acetamide SCHEMBL23647343 | 0.86 | — | — | |
| Acetic Acid SCHEMBL28385300 | 0.86 | LMNA (0.80) | LMNAALOX15BLMPMP22LDHA | |
| Acetamide SCHEMBL2232674 | 0.85 | — | — | |
| Acetamide SCHEMBL3337894 | 0.85 | LMNA (1.00) | LMNAALOX15BLMPMP22LDHA | |
| Acetamide SCHEMBL4953249 | 0.85 | LMNA (1.00) | LMNAALOX15BLMPMP22LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105636438-A | Pharmaceutical composition comprising an AMPK activator and a serotonin active agent and uses thereof | CHEN JIANHONG | 2016-06-01 | — | — | CN | claimed |
| CN-101717363-A | Method for preparing roxatidine acetate hydrochloride | CHANGZHOU BAOSHENGLONGCHENG PH | 2010-06-02 | — | — | CN | claimed |
| CN-1675201-A | N-substituted piperidine derivatives as serotonin receptor agents | ACADIA PHARM INC (US) | 2005-09-28 | — | — | CN | claimed |
| CN-105636438-A | Pharmaceutical composition comprising an AMPK activator and a serotonin active agent and uses thereof | CHEN JIANHONG | 2016-06-01 | — | — | CN | disclosed |
| CN-1443167-B | Azacyclo compounds for the treatment of 5-hydroxytryptamine related disorders | ACADIA PHARM INC | 2012-07-18 | — | — | CN | disclosed |
| CN-101717363-B | Method for preparing roxatidine acetate hydrochloride | CHANGZHOU BAOSHENGLONGCHENG PHARMACEUTICAL TECHNOLOGY CO LTD | 2012-05-09 | — | — | CN | disclosed |
| CN-101230033-B | New azabicycloalkane derivatives, preparing method and medicament combination containing the same | SERVIER LAB | 2011-03-09 | — | — | CN | disclosed |
| CN-101717363-A | Method for preparing roxatidine acetate hydrochloride | CHANGZHOU BAOSHENGLONGCHENG PH | 2010-06-02 | — | — | CN | disclosed |
| CN-101619057-A | N-substituted piperidine derivatives as serotonin receptor agents | ACADIA PHARM INC | 2010-01-06 | — | — | CN | disclosed |
| CN-100577160-C | Novel azabicyclo derivatives, preparation method thereof and pharmaceutical compositions containing same | SERVIER LAB | 2010-01-06 | — | — | CN | disclosed |
| CN-100509804-C | N-substituted piperidine derivatives as serotonin receptor agents | ACADIA PHARM INC (US) | 2009-07-08 | — | — | CN | disclosed |
| CN-101230033-A | New azabicycloalkane derivatives, preparing method and medicament combination containing the same | SERVIER LAB (FR) | 2008-07-30 | — | — | CN | disclosed |
| CN-101230034-A | Nitrogen hetero-cycle compounds for use in the treatment of 5-hydroxide tryptamines related diseases | ACADIA PHARM INC (US) | 2008-07-30 | — | — | CN | disclosed |
| CN-100389113-C | Nitrogen-containing heterocyclic compound and drug containing same | EISAI CO LTD (JP) | 2008-05-21 | — | — | CN | disclosed |
| CN-101014570-A | Piperidine derivative or pharmaceutically acceptable salt thereof | ASTELLAS PHARMA INC (JP) | 2007-08-08 | — | — | CN | disclosed |
| CN-1921848-A | Novel azabicyclo derivatives, preparation method thereof and pharmaceutical compositions containing same | SERVIER LAB (FR) | 2007-02-28 | — | — | CN | disclosed |
| CN-1675201-A | N-substituted piperidine derivatives as serotonin receptor agents | ACADIA PHARM INC (US) | 2005-09-28 | — | — | CN | disclosed |
| CN-1630650-A | Nitrogen-containing heterocyclic compound and drug containing same | EISAI CO LTD (JP) | 2005-06-22 | — | — | CN | disclosed |
| US-4465625-A | ANALGESICS | RICHTER GEDEON VEGYESZETI GYAR (HU) | 1984-08-14 | — | — | US | disclosed |