Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SI | P14410 | 1/20 | 0.30 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7647932 | 0.80 | USP2 (0.55) | USP2LMNAHSD17B10MEN1HPGD | |
| SCHEMBL3282103 | 0.80 | USP2 (0.55) | USP2LMNAHSD17B10MEN1HPGD | |
| SCHEMBL1463437 | 0.77 | USP2 (0.52) | USP2LMNAHSD17B10MEN1HPGD | |
| SCHEMBL10016881 | 0.73 | USP2 (0.48) | USP2LMNAHSD17B10MEN1HPGD | |
| SCHEMBL168730 | 0.72 | TSHR (0.43) | USP2LMNAHSD17B10MEN1HPGD | |
| SCHEMBL31356997 | 0.71 | USP2 (0.47) | USP2LMNAHSD17B10MEN1HPGD | |
| SCHEMBL11123261 | 0.68 | USP2 (0.43) | USP2LMNAHSD17B10MEN1HPGD | |
| SCHEMBL21174044 | 0.68 | TSHR (0.43) | USP2LMNAHSD17B10MEN1HPGD | |
| SCHEMBL5399544 | 0.67 | LMNA (0.39) | USP2LMNAHSD17B10MEN1HPGD | |
| SCHEMBL11750785 | 0.67 | MEN1 (0.47) | USP2LMNAHSD17B10MEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4443619-A | MULTISTEP PREPARATION OF MONOPOTASSIUM DIHYDROGEN THREO-EPOXYACONITATE FROM TRANSACONITIC ACID | HOFFMANN-LA ROCHE INC. (US) | 1984-04-17 | — | — | US | disclosed |
| US-4365070-A | B-LACTONE INTERMEDIATES THEREOF, ANORECTIC AGENTS FOR TREATMENT OBESITY | HOFFMANN-LA ROCHE INC. (US) | 1982-12-21 | — | — | US | disclosed |
| US-4354039-A | Chlorocitric acids | HOFFMANN-LA ROCHE INC. (US) | 1982-10-12 | — | — | US | disclosed |
| US-4352758-A | FROM TRANS-ACONITIC ACID | HOFFMANN-LA ROCHE INC. (US) | 1982-10-05 | — | — | US | disclosed |
| US-4340754-A | Process for making chlorocitric acid | HOFFMANN-LA ROCHE INC. (US) | 1982-07-20 | — | — | US | disclosed |
| US-4312885-A | ANORECTIC AGENTS FOR TREATMENT OF OBESITY | HOFFMANN-LA ROCHE INC. (US) | 1982-01-26 | — | — | US | disclosed |