Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830033 | 0.82 | TSHR (0.42) | TSHRHSD17B10MGAMGAASI | |
| Ammonia Solution, Strong SCHEMBL1306802 | 0.80 | TSHR (0.40) | TSHRHSD17B10MGAMGAASI | |
| SCHEMBL3282107 | 0.80 | TSHR (0.40) | TSHRHSD17B10MGAMGAASI | |
| SCHEMBL10011332 | 0.77 | TSHR (0.37) | TSHRHSD17B10MGAMGAASI | |
| SCHEMBL242271 | 0.77 | GAA (0.39) | TSHRHSD17B10MGAMGAASI | |
| SCHEMBL2420651 | 0.77 | USP2 (0.37) | TSHRHSD17B10MGAMGAASI | |
| SCHEMBL2905563 | 0.75 | USP2 (0.36) | TSHRHSD17B10MGAMGAASI | |
| SCHEMBL10011809 | 0.75 | TSHR (0.36) | TSHRHSD17B10MGAMGAASI | |
| SCHEMBL10010665 | 0.74 | TSHR (0.34) | TSHRHSD17B10MGAMGAASI | |
| SCHEMBL17050951 | 0.74 | TSHR (0.34) | TSHRHSD17B10MGAMGAASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4443619-A | MULTISTEP PREPARATION OF MONOPOTASSIUM DIHYDROGEN THREO-EPOXYACONITATE FROM TRANSACONITIC ACID | HOFFMANN-LA ROCHE INC. (US) | 1984-04-17 | — | — | US | disclosed |
| US-4365070-A | B-LACTONE INTERMEDIATES THEREOF, ANORECTIC AGENTS FOR TREATMENT OBESITY | HOFFMANN-LA ROCHE INC. (US) | 1982-12-21 | — | — | US | disclosed |
| US-4354039-A | Chlorocitric acids | HOFFMANN-LA ROCHE INC. (US) | 1982-10-12 | — | — | US | disclosed |
| US-4352758-A | FROM TRANS-ACONITIC ACID | HOFFMANN-LA ROCHE INC. (US) | 1982-10-05 | — | — | US | disclosed |
| US-4340754-A | Process for making chlorocitric acid | HOFFMANN-LA ROCHE INC. (US) | 1982-07-20 | — | — | US | disclosed |
| US-4312885-A | ANORECTIC AGENTS FOR TREATMENT OF OBESITY | HOFFMANN-LA ROCHE INC. (US) | 1982-01-26 | — | — | US | disclosed |