Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6209667 | 0.81 | SMN1; SMN2 (0.44) | ALDH1A1SMN1; SMN2KMT2AMAPTRAB9A | |
| SCHEMBL8906464 | 0.77 | PIN1 (0.39) | ALDH1A1KMT2ARAB9ALMNAMEN1 | |
| SCHEMBL19483160 | 0.74 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2KMT2AMAPTRAB9A | |
| SCHEMBL16576933 | 0.71 | MAPT (0.50) | ALDH1A1KMT2AMAPTRAB9AMEN1 | |
| SCHEMBL14851767 | 0.71 | MAPT (0.50) | ALDH1A1KMT2AMAPTRAB9AMEN1 | |
| SCHEMBL14851770 | 0.71 | KMT2A (0.40) | ALDH1A1SMN1; SMN2KMT2AMAPTRAB9A | |
| SCHEMBL9384965 | 0.71 | CA1 (0.39) | ALDH1A1KMT2AMAPTRAB9AMEN1 | |
| SCHEMBL16576941 | 0.71 | MAPT (0.50) | ALDH1A1KMT2AMAPTRAB9AMEN1 | |
| SCHEMBL27455916 | 0.70 | PIN1 (0.34) | ALDH1A1SMN1; SMN2KMT2AMAPTRAB9A | |
| SCHEMBL17233682 | 0.69 | MAPT (0.41) | ALDH1A1KMT2AMAPTRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4454326-A | 5-Aroyl 6-chloro or 6-bromo 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1,1-di-carboxylates | SYNTEX (U.S.A.) INC. (US) | 1984-06-12 | — | — | US | disclosed |
| US-4347187-A | Process for preparing 5-aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein | SYNTEX (U.S.A.) INC. (US) | 1982-08-31 | — | — | US | disclosed |