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PIN1

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 · Q13526 · PIN1 on Sugi Atlas →

55,811 patent compounds predicted against PIN1, 31,623 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL57678 SCHEMBL57678 0.53 19/20
SCHEMBL316552 SCHEMBL316552 1.00 12/20
SCHEMBL501349 SCHEMBL501349 0.54 10/20
6-O-Benzylguanine 6-O-Benzylguanine (SCHEMBL61740) 1.00 9/20
SCHEMBL307028 SCHEMBL307028 0.65 8/20
SCHEMBL306660 SCHEMBL306660 0.62 8/20
SCHEMBL375418 SCHEMBL375418 0.59 8/20
SCHEMBL384450 SCHEMBL384450 0.51 8/20
SCHEMBL213561 SCHEMBL213561 0.48 8/20
SCHEMBL445404 SCHEMBL445404 0.49 7/20
SCHEMBL501298 SCHEMBL501298 0.57 6/20
SCHEMBL168495 SCHEMBL168495 0.50 6/20
SCHEMBL202663 SCHEMBL202663 0.45 6/20
SCHEMBL72543 SCHEMBL72543 0.62 5/20
SCHEMBL176930 SCHEMBL176930 0.58 5/20
SCHEMBL203766 SCHEMBL203766 0.53 5/20
SCHEMBL442962 SCHEMBL442962 0.49 5/20
SCHEMBL307928 SCHEMBL307928 0.46 5/20
SCHEMBL456753 SCHEMBL456753 0.44 5/20
SCHEMBL501603 SCHEMBL501603 0.55 4/20

Clinical trials — most relevant to PIN1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Physiological Intermolecular Modification Spectroscopy (PIMS) in Ulcerative Colitis With Golimumab PHASE4UNKNOWN
OPTImization of the Dose of tacroliMUS by Bayesian Prediction PHASE4COMPLETED
Efficacy, Safety, Pharmacokinetics of ICP-488 in Patients With Moderate to Severe Plaque Psoriasis PHASE3RECRUITING
Trial of Trientine Plus Pegylated Liposomal Doxorubicin and Carboplatin in Epithelial Ovarian Cancer PHASE1/PHASE2COMPLETED
Lapatinib Ditosylate in Treating Patients With Unresectable Liver or Biliary Tract Cancer PHASE2COMPLETED
9-ING-41 in Patients With Advanced Cancers PHASE2ACTIVE_NOT_RECRUITING
Sapanisertib and Serabelisib (PIKTOR) With Paclitaxel and a Substudy With an Insulin-Suppressing Diet in Patients With Advanced/Recurrent Endometrial Cancer PHASE2RECRUITING
Rapamycin for Immunosuppression and B Cell Modulation Post Stem Cell Transplant for Acute Lymphoblastic Leukemia (ALL) PHASE2COMPLETED
Clinical Study of SPH3348 Tablets, a C-Met Inhibitor, in Patients with Advanced Solid Tumors PHASE1COMPLETED
The Safety and Pharmacokinetics Preliminary Efficacy of IMP7068 in Patients With Advanced Solid Tumors PHASE1UNKNOWN
A Trial of the Protease Inhibitor Nelfinavir and Concurrent Radiation and Temozolomide in Patients With WHO Grade IV Glioma PHASE1COMPLETED
The MEseNchymal coviD-19 Trial: MSCs in Adults With Respiratory Failure Due to COVID-19 or Another Underlying Cause PHASE1COMPLETED
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease EARLY_PHASE1RECRUITING
Immunohistochemical Expression of Excision Repair Cross Complementation Group 1 (ERCC1) in Laryngeal Squamous Cell Carcinoma and Its Correlation With Response to Radiotherapy. nanUNKNOWN
Lymphoid Tyrosine Phosphatase Gene Polymorphisms in Inflammatory Bowel Disease nanUNKNOWN
Mechanism and Immune Function Analysis of SARS-CoV-2 Infection in Hematologic Tumors nanACTIVE_NOT_RECRUITING
Study for the Multidimensional Analyses of Resistance and Toxicity to Immune- and Targeted-therapies. nanUNKNOWN
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Identification of Acute Intermittent Porphyria Modifying Genes nanRECRUITING
Remote Ischemic Postconditioning Increases HIF-1α Plasma Levels and Improves Cardiac Markers After Cardiac Surgery nanCOMPLETED
Biomarkers in the Diagnosis and Prognosis of NAFLD nanRECRUITING
Establishment of Human Cellular Disease Models for Wilson Disease nanCOMPLETED
Genetic and Epigenetic Variations in Heterokaryotypic Monozygotic Twins Discordant for Down Syndrome nanRECRUITING
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population nanCOMPLETED
Chinese Psoriasis Real World Evidence Research nanRECRUITING
Expression of Fas Protein in Skin Biopsies of Participants With Scarring Alopecia nanCOMPLETED
Protein Expression as a Potential Diagnostic Biomarker of Cervical Dysplasia and/or Cancer nanCOMPLETED
Plant Extracted Natural Compounds Impact on Stage IV Breast Cancer Survival Time and Remission. nanUNKNOWN
IL-17 Role in Variants of Psoriasis nanCOMPLETED
IKBKB Gene Polymorphism (Single Nucleotide Polymorphism) (SNP) in Psoriatic and Psoriatic Arthritis Patients nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PIN1 binder may also engage these)

ProteinNameSimilarity
Q9QUR7 — 1.000 Q9QUR7 →
Q4R383 — 1.000 Q4R383 →
Q5BIN5 — 1.000 Q5BIN5 →
P0C1J8 — 0.989 P0C1J8 →
O74448 — 0.988 O74448 →
P54353 — 0.986 P54353 →
P22696 — 0.985 P22696 →
Q94G00 — 0.983 Q94G00 →
Q9SL42 — 0.981 Q9SL42 →
Q9LEK8 — 0.981 Q9LEK8 →
P0DMT5 — 0.980 P0DMT5 →
O60045 — 0.979 O60045 →
Q4UG71 — 0.978 Q4UG71 →
Q941L3 — 0.972 Q941L3 →
A9S0B8 — 0.972 A9S0B8 →
Q5U2T9 — 0.971 Q5U2T9 →
Q9TRY0 — 0.970 Q9TRY0 →
C1BM18 — 0.970 C1BM18 →
Q19683 — 0.970 Q19683 →
Q5RF88 — 0.970 Q5RF88 →
Q4R5U5 — 0.970 Q4R5U5 →
Q5XIP6 — 0.970 Q5XIP6 →
O61660 — 0.969 O61660 →
O49809 — 0.969 O49809 →
O65251 — 0.969 O65251 →
Q39102 — 0.969 Q39102 →
Q9VL78 — 0.969 Q9VL78 →
P93648 — 0.969 P93648 →
Q68EH8 — 0.969 Q68EH8 →
P27124 — 0.969 P27124 →