Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rolgamidine SCHEMBL637007 | 0.70 | BACE1 (0.40) | LMNAMAPTMEN1KMT2A | |
| SCHEMBL11537621 | 0.70 | SLC6A9 (0.34) | ALDH1A1MAPTSLC6A9 | |
| SCHEMBL11537623 | 0.70 | SLC6A9 (0.34) | ALDH1A1MAPTSLC6A9 | |
| SCHEMBL11537617 | 0.70 | SLC6A9 (0.34) | ALDH1A1MAPTSLC6A9 | |
| SCHEMBL22693278 | 0.70 | FUCA1 (0.38) | FFAR3CA12CA9 | |
| SCHEMBL9325002 | 0.68 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL1 | |
| SCHEMBL13248935 | 0.67 | RECQL (0.41) | SMN1; SMN2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL13069241 | 0.67 | RECQL (0.41) | SMN1; SMN2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL17756759 | 0.67 | RECQL (0.41) | SMN1; SMN2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL3113944 | 0.67 | RECQL (0.41) | SMN1; SMN2ALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4443467-A | N-DIAMINOMETHYLENE-(2,5-DIHYDRO-1H-PYRROL-1-YL)ACETAMIDES | JOHN WYETH & BROTHER, LIMITED (GB) | 1984-04-17 | — | — | US | disclosed |
| EP-0040947-A1 | Use of guanidines for manufacturing antidiarrhoeal medicaments and antidiarrhoeal compositions containing these guanidines | JOHN WYETH & BROTHER LIMITED (GB) | 1981-12-02 | — | — | EP | disclosed |
| US-4140793-A | HYPOGLYCEMIC AGENTS, ANTIULCER AGENTS | JOHN WYETH & BROTHER, LTD. (GB) | 1979-02-20 | — | — | US | disclosed |