Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.66 |
| ▸ | CTSL | P07711 | 6/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.52 |
| ▸ | TGM2 | P21980 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11514580 | 1.00 | ATM (0.66) | ATMCTSLCTSSTGM2RAB9A | |
| SCHEMBL10967450 | 0.90 | ATM (0.57) | ATMCTSLCTSSTGM2RAB9A | |
| SCHEMBL10967446 | 0.90 | ATM (0.54) | ATMCTSLCTSSTGM2RAB9A | |
| SCHEMBL11293241 | 0.90 | ATM (0.54) | ATMCTSLCTSSTGM2RAB9A | |
| SCHEMBL11216821 | 0.89 | ATM (0.53) | ATMCTSLTGM2RAB9AMAPT | |
| SCHEMBL11204903 | 0.88 | ATM (0.58) | ATMCTSLCTSSTGM2 | |
| SCHEMBL11533827 | 0.87 | SMN1; SMN2 (0.56) | ATMCTSLCTSSRAB9AMAPT | |
| SCHEMBL11692430 | 0.86 | ATM (0.49) | ATMCTSLTGM2RAB9ANPC1 | |
| SCHEMBL1362502 | 0.85 | ATM (0.77) | ATMCTSLCTSS | |
| SCHEMBL3255533 | 0.85 | ATM (0.77) | ATMCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034443-B1 | BETA-LACTAM ANTIBACTERIAL COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1984-09-26 | — | — | EP | disclosed |
| US-4444771-A | Azeto triazolo pyrazine β-lactam antibacterial agents | BEECHAM GROUP LIMITED (GB) | 1984-04-24 | — | — | US | disclosed |
| US-4407815-A | AMINO ACID DERIVATIVE ANTIBIOTICS | BEECHAM GROUP LIMITED (GB) | 1983-10-04 | — | — | US | disclosed |
| EP-0048096-A1 | Beta-lactam antibacterial agents | BEECHAM GROUP PLC (GB) | 1982-03-24 | — | — | EP | disclosed |
| EP-0034443-A2 | Beta-lactam antibacterial compounds, their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1981-08-26 | — | — | EP | disclosed |