Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 11/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11880121 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1LMNAHTTMAPT | |
| SCHEMBL16922173 | 0.85 | MAPT (0.53) | SMN1; SMN2ALDH1A1LMNAHTTMAPT | |
| SCHEMBL5550221 | 0.82 | HTT (0.62) | SMN1; SMN2ALDH1A1LMNAHTTMAPT | |
| SCHEMBL11321526 | 0.81 | MMP1 (0.50) | SMN1; SMN2ALDH1A1LMNAHTTMAPT | |
| SCHEMBL11321533 | 0.81 | MMP1 (0.50) | SMN1; SMN2ALDH1A1LMNAHTTMAPT | |
| SCHEMBL11144045 | 0.79 | MAPT (0.48) | SMN1; SMN2ALDH1A1LMNAHTTMAPT | |
| SCHEMBL11144053 | 0.79 | MAPT (0.48) | SMN1; SMN2ALDH1A1LMNAHTTMAPT | |
| SCHEMBL11462228 | 0.78 | MAPT (0.49) | SMN1; SMN2ALDH1A1LMNAHTTMAPT | |
| SCHEMBL11473776 | 0.78 | MAPT (0.49) | SMN1; SMN2ALDH1A1LMNAHTTMAPT | |
| SCHEMBL6816296 | 0.77 | MAPT (0.60) | SMN1; SMN2ALDH1A1LMNAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0008421-B1 | BENZODIAZEPINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-02-08 | — | — | EP | disclosed |