Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 17/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11068416 | 1.00 | TBXAS1 (0.59) | TBXAS1AKR1C3CYP17A1CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL11065556 | 0.99 | TBXAS1 (0.61) | TBXAS1AKR1C3CYP17A1CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL11065552 | 0.99 | TBXAS1 (0.61) | TBXAS1AKR1C3CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL11063685 | 0.86 | TBXAS1 (0.74) | TBXAS1 | |
| SCHEMBL11063681 | 0.86 | TBXAS1 (0.74) | TBXAS1 | |
| Hydrochloric Acid SCHEMBL11061685 | 0.85 | TBXAS1 (0.77) | TBXAS1 | |
| Hydrochloric Acid SCHEMBL11061680 | 0.85 | TBXAS1 (0.77) | TBXAS1 | |
| SCHEMBL11061416 | 0.84 | TBXAS1 (0.70) | TBXAS1AKR1C3CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL11061432 | 0.84 | TBXAS1 (0.70) | TBXAS1AKR1C3CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL11067879 | 0.83 | TBXAS1 (0.43) | TBXAS1CYP17A1CYP11B1CYP11B2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4271170-A | THROMBOXANE SYNTHETASE ENZYME INHIBITOR USEFUL IN TREATING INFLAMMATION, HYPERTENSION, THROMBUS, CEREBRAL APOPLEXY, ASTHMA, AND CARDIOVASCULAR DISORDERS | ONO PHARMACEUTICAL CO., LTD., (JP) | 1981-06-02 | — | — | US | claimed |
| US-4427682-A | ANTICOAGULANTS, ANTIINFLAMMATORY, HYPOTENSIVE, OR ANTIALLERGEN AGENTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1984-01-24 | — | — | US | disclosed |
| US-4317828-A | ANTIINFLAMMATORY AGENTS, HYPOTENSIVE AGENTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1982-03-02 | — | — | US | disclosed |
| US-4271170-A | THROMBOXANE SYNTHETASE ENZYME INHIBITOR USEFUL IN TREATING INFLAMMATION, HYPERTENSION, THROMBUS, CEREBRAL APOPLEXY, ASTHMA, AND CARDIOVASCULAR DISORDERS | ONO PHARMACEUTICAL CO., LTD., (JP) | 1981-06-02 | — | — | US | disclosed |