SCHEMBL11068751

SCHEMBL11068751

OCc1ccc(-c2ncc(Cl)cc2Cl)cc1O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 1/20 0.42
BRAF P15056 3/20 0.41
GUSB P08236 1/20 0.37
MAPK1 P28482 2/20 0.36
MAP2K4 P45985 1/20 0.36
MAPKAPK2 P49137 1/20 0.36
MAPKAPK3 Q16644 1/20 0.36
MAPK6 Q16659 1/20 0.36
METAP2 P50579 1/20 0.36
ADORA2A P29274 1/20 0.35
JAK3 P52333 1/20 0.35
PTGS1 P23219 2/20 0.33
PTGS2 P35354 2/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
NOTUM Q6P988 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9362233 0.82 GUSB (0.51) CNR2GUSBMAPK1ADORA2AJAK3
SCHEMBL10376457 0.78 CYP3A4 (0.50) CNR2BRAFGUSBMAPK1METAP2
SCHEMBL18356746 0.75 MAPK1 (0.53) CNR2MAPK1ADORA2AMEN1KMT2A
SCHEMBL11503556 0.75 CNR2 (0.43) CNR2BRAFGUSBMAPK1METAP2
SCHEMBL11063390 0.75 TDP1 (0.42) CNR2GUSBMAPK1METAP2ADORA2A
SCHEMBL11464843 0.74 PRKAB2 (0.37) CNR2BRAFGUSBMAPK1METAP2
SCHEMBL16675782 0.74 MAP2K4 (0.55) CNR2BRAFMAP2K4CYP2C9
SCHEMBL11464455 0.72 CNR2 (0.36) CNR2GUSBMAPK1METAP2ADORA2A
SCHEMBL10377972 0.71 CNR2 (0.39) CNR2BRAFGUSBMAPK1METAP2
SCHEMBL11463826 0.71 CNR2 (0.36) CNR2GUSBMAPK1METAP2ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4425156-A Pyridyl-2-oxyphenyloxime derivatives, and their use as herbicides CIBA-GEIGY CORPORATION (US) 1984-01-10 US disclosed
EP-0023891-B1 PYRIDYL-2-OXY-PHENYLOXIME ETHERS AND ESTERS, THEIR PREPARATION AND THEIR USE AS HERBICIDES CIBA-GEIGY AG (CH) 1983-09-14 EP disclosed
US-4394158-A PLANT GROWTH REGULATORS AND SAFENING AGENTS CIBA-GEIGY CORPORATION (US) 1983-07-19 US disclosed
US-4394157-A PLANT SAFTENING AGENTS CIBA-GEIGY CORPORATION (US) 1983-07-19 US disclosed
US-4322241-A Pyridyl-2-oxyphenyloxime derivatives, and their use as herbicides CIBA-GEIGY CORPORATION (US) 1982-03-30 US disclosed
EP-0023891-A1 Pyridyl-2-oxy-phenyloxime ethers and esters, their preparation and their use as herbicides CIBA-GEIGY AG (CH) 1981-02-11 EP disclosed