Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.53 |
| ▸ | CA1 | P00915 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL394474 | 0.90 | CA2 (0.63) | CA2CA1MAPK1ACHEGAA | |
| SCHEMBL609048 | 0.84 | CA2 (0.53) | CA2CA1MAPK1ACHEGAA | |
| Ethylene Glycol SCHEMBL9625020 | 0.83 | CA2 (0.63) | CA2CA1MAPK1ACHEGAA | |
| SCHEMBL1428342 | 0.83 | CA2 (0.52) | CA2CA1MAPK1ACHEATM | |
| SCHEMBL9327517 | 0.82 | CA2 (0.61) | CA2CA1MAPK1ACHEGAA | |
| SCHEMBL154056 | 0.81 | CA2 (0.70) | CA2CA1MAPK1ACHEGAA | |
| SCHEMBL8985885 | 0.81 | CA2 (0.56) | CA2CA1MAPK1ACHEGAA | |
| SCHEMBL9167701 | 0.81 | CA2 (0.56) | CA2CA1MAPK1ACHEGAA | |
| SCHEMBL17626978 | 0.81 | CA2 (0.56) | CA2CA1MAPK1ACHEGAA | |
| SCHEMBL474747 | 0.81 | CA2 (0.56) | CA2CA1MAPK1ACHEGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4483974-A | POLYMERIZATION INHIGITION BY BLOCKING WITH AMINE, HYDRAZINE, OR HYDRAZIDE | BAYER AKTIENGESELLSCHAFT (DE) | 1984-11-20 | — | — | US | disclosed |