SCHEMBL1106905

SCHEMBL1106905

CCOC(=O)C=Cc1cc(C)ccc1O

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 1/20 0.61
DPP4 P27487 1/20 0.61
HSD17B1 P14061 1/20 0.57
HSD17B2 P37059 1/20 0.57
MAOB P27338 1/20 0.56
ESR1 P03372 1/20 0.55
CYP3A4 P08684 2/20 0.55
CA12 O43570 1/20 0.54
CA1 P00915 1/20 0.54
CA2 P00918 1/20 0.54
CA7 P43166 1/20 0.54
CA9 Q16790 1/20 0.54
CA14 Q9ULX7 1/20 0.54
MAPT P10636 3/20 0.53
ALDH1A1 P00352 2/20 0.53
KDM4E B2RXH2 1/20 0.53
MEN1 O00255 1/20 0.53
TP53 P04637 1/20 0.53
CYP1A2 P05177 1/20 0.53
CYP2C9 P11712 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3123781 1.00 TTR (0.61) TTRDPP4HSD17B1HSD17B2MAOB
SCHEMBL3366451 0.88 ALDH1A1 (0.69) TTRDPP4HSD17B1HSD17B2MAOB
SCHEMBL31618785 0.88 ALDH1A1 (0.69) TTRDPP4HSD17B1HSD17B2MAOB
SCHEMBL3366448 0.88 ALDH1A1 (0.69) TTRDPP4HSD17B1HSD17B2MAOB
SCHEMBL31683004 0.88 TTR (0.57) TTRDPP4HSD17B1HSD17B2MAOB
SCHEMBL28283049 0.85 TTR (0.58) TTRDPP4HSD17B1HSD17B2MAOB
SCHEMBL2537052 0.85 TTR (0.58) TTRDPP4HSD17B1HSD17B2MAOB
SCHEMBL28281653 0.85 TTR (0.58) TTRDPP4HSD17B1HSD17B2MAOB
SCHEMBL13764832 0.85 TTR (0.58) TTRDPP4HSD17B1HSD17B2MAOB
SCHEMBL28283048 0.85 TTR (0.58) TTRDPP4HSD17B1HSD17B2MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8153793-B2 Sulfonamide derivative having PGD2 receptor antagonistic activity SHIONOGI & CO., LTD. (JP) 2012-04-10 US disclosed
EP-0936211-B1 Aryl-acrylic acid esters useful as precursors for organoleptic compounds GIVAUDAN SA (CH) 2010-07-07 EP disclosed
US-6096918-A USEFUL FOR THE DELIVERY OF ORGANOLEPTIC COMPOUNDS, ESPECIALLY FOR FLAVORS, FRAGRANCES, MASKING AGENTS AND ANTIMICROBIAL COMPOUNDS. THEY CAN ALSO DELIVER FLUORESCENT WHITENING AGENTS. GIVAUDAN ROURE (INTERNATIONAL) SA (CH) 2000-08-01 US disclosed
EP-0936211-A2 Aryl-acrylic acid esters useful as precursors for organoleptic compounds Givaudan Roure (International) S.A. (CH) 1999-08-18 EP disclosed
EP-0769005-A2 PLA 2? INHIBITORS AND THEIR USE FOR INHIBITION OF INTESTINAL CHOLESTEROL ABSORPTION WARNER-LAMBERT COMPANY (US) 1997-04-23 EP disclosed
WO-1996001253-A2 PLA2 INHIBITORS AND THEIR USE FOR INHIBITION OF INTESTINAL CHOLESTEROL ABSORPTION WARNER-LAMBERT COMPANY (US) 1996-01-18 WO disclosed