SCHEMBL11069423

SCHEMBL11069423

Clc1ccc(P(c2ccccc2Cl)c2ccccc2Cl)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 7/20 0.39
LMNA P02545 3/20 0.39
CYP1A2 P05177 1/20 0.37
CYP2A6 P11509 1/20 0.36
CYP3A4 P08684 2/20 0.36
TDP1 Q9NUW8 2/20 0.36
FLT1 P17948 1/20 0.36
FLT4 P35916 1/20 0.36
KDR P35968 1/20 0.36
HIF1A Q16665 2/20 0.34
KDM4E B2RXH2 2/20 0.34
MAPT P10636 2/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
NR1I2 O75469 1/20 0.34
ABCB11 O95342 1/20 0.34
NR3C1 P04150 1/20 0.34
PGR P06401 1/20 0.34
ADRA2A P08913 1/20 0.34
ADORA3 P0DMS8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2454266 0.86 CYP3A4 (0.52) TSHRLMNACYP1A2CYP2A6CYP3A4
SCHEMBL30046611 0.86 CYP3A4 (0.52) TSHRLMNACYP1A2CYP2A6CYP3A4
SCHEMBL31258429 0.82 CYP3A4 (0.48) TSHRLMNACYP1A2CYP2A6CYP3A4
SCHEMBL9854456 0.81 CYP3A4 (0.52) TSHRLMNACYP1A2CYP2A6CYP3A4
SCHEMBL29518446 0.81 CYP3A4 (0.52) TSHRLMNACYP1A2CYP2A6CYP3A4
SCHEMBL1579385 0.80 TSHR (0.53) TSHRLMNACYP1A2CYP2A6CYP3A4
SCHEMBL29672644 0.79 CYP3A4 (0.50) TSHRLMNACYP1A2CYP2A6CYP3A4
SCHEMBL29996019 0.79 CYP3A4 (0.50) TSHRLMNACYP1A2CYP2A6CYP3A4
SCHEMBL31158056 0.79 CYP3A4 (0.50) TSHRLMNACYP1A2CYP2A6CYP3A4
SCHEMBL9624292 0.78 LMNA (0.36) TSHRLMNACYP1A2CYP3A4TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4483801-A SULFONATING TRIARYLPHOSPHINE, HUDROLYSIS, AND SOLVENT EXTRACTION RHONE-POULENC CHIMIE DE BASE (FR) 1984-11-20 US disclosed