Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | FASN | P49327 | 1/20 | 0.39 |
| ▸ | TCF4 | P15884 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17420773 | 0.85 | HSP90AB1 (0.44) | TSHRALDH1A1HSD17B10TDP1SMN1; SMN2 | |
| SCHEMBL7476851 | 0.84 | HSD17B10 (0.46) | TSHRHPGDALDH1A1HSD17B10ALOX15 | |
| SCHEMBL507731 | 0.81 | TSHR (0.46) | TSHRHPGDALDH1A1HSD17B10ALOX15 | |
| SCHEMBL6699177 | 0.80 | FASN (0.41) | HPGDALDH1A1RECQLTDP1HSD17B3 | |
| SCHEMBL11483328 | 0.77 | HTT (0.44) | ALDH1A1HSD17B10HSD17B3HTTSTS | |
| SCHEMBL9559780 | 0.76 | MAPT (0.49) | TSHRHPGDALDH1A1HSD17B10ALOX15 | |
| SCHEMBL6232283 | 0.76 | CYP3A4 (0.40) | TSHRHPGDALDH1A1HSD17B10ALOX15 | |
| SCHEMBL6109740 | 0.75 | PTGER4 (0.47) | TSHRHPGDALDH1A1HSD17B10ALOX15 | |
| SCHEMBL11220438 | 0.75 | ALDH1A1 (0.41) | TSHRHPGDALDH1A1HSD17B10ALOX15 | |
| SCHEMBL55681 | 0.74 | ALDH1A1 (0.61) | TSHRHPGDALDH1A1HSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4476132-A | Acylquinolinone derivatives, and antiallergic preparations and methods of inhibiting allergic reactions using them | CIBA-GEIGY CORPORATION (US) | 1984-10-09 | — | — | US | disclosed |
| EP-0062001-A2 | Acyl quinolinone derivatives, processes for their preparation, pharmaceutical compositions containing them and their use | CIBA-GEIGY AG (CH) | 1982-10-06 | — | — | EP | disclosed |