Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | PRCP | P42785 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 2/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3263577 | 0.83 | GBA1 (0.50) | MEN1KMT2ACYP3A4CYP2D6SLC22A1 | |
| SCHEMBL3263571 | 0.83 | GBA1 (0.50) | MEN1KMT2ACYP3A4CYP2D6SLC22A1 | |
| SCHEMBL17121746 | 0.79 | MEN1 (0.51) | MEN1KMT2ACYP3A4CYP2D6HTR2A | |
| SCHEMBL17120414 | 0.79 | MEN1 (0.51) | MEN1KMT2ACYP3A4CYP2D6HTR2A | |
| SCHEMBL29570896 | 0.79 | MEN1 (0.51) | MEN1KMT2ACYP3A4CYP2D6HTR2A | |
| SCHEMBL2264568 | 0.79 | MEN1 (0.51) | MEN1KMT2ACYP3A4CYP2D6HTR2A | |
| SCHEMBL26201345 | 0.79 | MEN1 (0.51) | MEN1KMT2ACYP3A4CYP2D6HTR2A | |
| SCHEMBL3118805 | 0.77 | MEN1 (0.50) | MEN1KMT2ACYP3A4CYP2D6HTR2A | |
| SCHEMBL9544082 | 0.77 | MEN1 (0.50) | MEN1KMT2ACYP3A4CYP2D6HTR2A | |
| SCHEMBL27822582 | 0.76 | CYP2D6 (0.38) | MEN1KMT2ACYP3A4CYP2D6HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0042659-B1 | 5,6,6A,7-TETRAHYDRO-4H-DIBENZ(DE,G)ISOQUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1984-08-29 | — | — | EP | disclosed |
| US-4425350-A | 5,6,6a,7-Tetrahydro-4H-dibenz(de,g)-isoquinoline derivatives, and their use for treating central nervous system disorders | WARNER-LAMBERT COMPANY (US) | 1984-01-10 | — | — | US | disclosed |
| EP-0042659-A1 | 5,6,6a,7-Tetrahydro-4H-dibenz(de,g)isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1981-12-30 | — | — | EP | disclosed |