Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.37 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 3/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KLF5 | Q13887 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenethylamine SCHEMBL11073573 | 1.00 | AKR1B1 (0.46) | AKR1B1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL9589020 | 0.88 | AKR1B1 (0.53) | AKR1B1RAB9ANPC1MAPTAKR1B10 | |
| SCHEMBL9591095 | 0.88 | AKR1B1 (0.53) | AKR1B1RAB9ANPC1MAPTAKR1B10 | |
| SCHEMBL10647002 | 0.88 | AKR1B1 (0.53) | AKR1B1RAB9ANPC1MAPTAKR1B10 | |
| SCHEMBL10653318 | 0.80 | AKR1B1 (0.47) | AKR1B1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL10650449 | 0.80 | AKR1B1 (0.47) | AKR1B1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL10571022 | 0.79 | AKR1B1 (0.39) | AKR1B1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL10754485 | 0.77 | AKR1B1 (0.49) | AKR1B1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL10571458 | 0.77 | AKR1B1 (0.53) | AKR1B1RAB9ANPC1MAPTAKR1B10 | |
| SCHEMBL10575352 | 0.77 | ALDH1A1 (0.36) | AKR1B1RAB9ANPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0111387-A1 | Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis of sorbinil | PFIZER INC. (US) | 1984-06-20 | — | — | EP | disclosed |
| EP-0109232-A1 | Sorbinal by optical resolution of precursor 6-fluro-4-ureidochroman-4-carboxylic acid | PFIZER INC. (US) | 1984-05-23 | — | — | EP | disclosed |