Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.41 |
| ▸ | SGPL1 | O95470 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 5/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
| ▸ | GRK5 | P34947 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10247009 | 0.83 | HDAC8 (0.57) | HDAC8HDAC6 | |
| SCHEMBL4869535 | 0.80 | PARP14 (0.39) | KDM1AHSD17B3KDM4EMCHR1PARP14 | |
| SCHEMBL10246917 | 0.78 | HDAC6 (0.51) | SGPL1S1PR1HDAC8HDAC6 | |
| SCHEMBL8434564 | 0.77 | DRD2 (0.60) | KDM1AKDM4E | |
| SCHEMBL367380 | 0.76 | KDM1A (0.46) | KDM1AHSD17B3PARP10PARP1HDAC8 | |
| SCHEMBL4790634 | 0.74 | GRIN2B (0.59) | DAPK3JAK2CSF1RRETPRKACA | |
| SCHEMBL26052456 | 0.74 | GRIN2B (0.59) | DAPK3JAK2CSF1RRETPRKACA | |
| SCHEMBL29683570 | 0.74 | GRIN2B (0.59) | DAPK3JAK2CSF1RRETPRKACA | |
| SCHEMBL21168435 | 0.72 | HSD17B3 (0.55) | KDM1AHSD17B3KDM4EPARP1 | |
| SCHEMBL27943409 | 0.72 | PDE4A (0.49) | KDM1APARP10PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4462923-A | Disubstituted pyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1984-07-31 | — | — | US | disclosed |