Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 6/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PTGES | O14684 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11080583 | 0.93 | KDM4E (0.49) | KDM4EDRD2AURKACHEK1EGFR | |
| SCHEMBL11084830 | 0.86 | MAPT (0.46) | KDM4ECHEK1EGFRKDRALDH1A1 | |
| SCHEMBL11073324 | 0.84 | KDM4E (0.43) | KDM4EDRD2AURKACHEK1EGFR | |
| SCHEMBL11762255 | 0.82 | NPC1 (0.65) | KDM4EDRD2AURKACHEK1EGFR | |
| SCHEMBL11827086 | 0.78 | PTGS2 (0.53) | KDM4EDRD2AURKAALDH1A1PTGES | |
| SCHEMBL1960110 | 0.77 | MAPK1 (0.50) | KDM4EDRD2AURKACHEK1EGFR | |
| SCHEMBL6268028 | 0.77 | CYP2C9 (0.54) | KDM4EAURKAALDH1A1LMNAMAPT | |
| SCHEMBL11765733 | 0.77 | NPC1 (0.68) | KDM4ECHEK1EGFRKDRALDH1A1 | |
| SCHEMBL4022996 | 0.77 | KMT2A (0.51) | KDM4EDRD2KDRALDH1A1LMNA | |
| SCHEMBL11408123 | 0.77 | KDM4E (0.64) | KDM4EDRD2AURKAALDH1A1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0022906-B1 | PROCESS FOR THE PREPARATION OF PYRAZOLE DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-08-08 | — | — | EP | disclosed |
| EP-0022906-A1 | Process for the preparation of pyrazole derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1981-01-28 | — | — | EP | disclosed |