⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6474091 | 0.78 | ALDH1A1 (0.36) | — | |
| SCHEMBL14727991 | 0.76 | — | — | |
| SCHEMBL7352222 | 0.75 | — | — | |
| SCHEMBL10616300 | 0.75 | — | — | |
| SCHEMBL2933578 | 0.75 | — | — | |
| SCHEMBL2869460 | 0.75 | — | — | |
| SCHEMBL2869462 | 0.75 | — | — | |
| SCHEMBL2094376 | 0.75 | — | — | |
| SCHEMBL4405692 | 0.73 | — | — | |
| SCHEMBL17507446 | 0.73 | ALDH1A1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 134 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240002355-A1 | PROCESS FOR THE MANUFACTURE OF TETRAZOLE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2024-01-04 | — | — | US | claimed |
| EP-4247799-A1 | NEW PROCESS FOR THE MANUFACTURE OF TETRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-09-27 | — | — | EP | claimed |
| CN-116635372-A | Novel process for producing tetrazole derivatives | 豪夫迈·罗氏有限公司 | 2023-08-22 | — | — | CN | claimed |
| WO-2022106669-A1 | NEW PROCESS FOR THE MANUFACTURE OF TETRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2022-05-27 | — | — | WO | claimed |
| US-12495798-B2 | Nicotinamide compound and herbicidal composition comprising compound | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2025-12-16 | — | — | US | disclosed |
| US-20250326759-A1 | PROCESS FOR PREPARING 1-[5-TERT-BUTYL-3-[(1-METHYLTETRAZOL-5-YL)METHYL]TRIAZOLO[4,5-D]PYRIMIDIN-7-YL]PYRROLIDIN-3-OL | HOFFMANN-LA ROCHE INC. (US) | 2025-10-23 | — | — | US | disclosed |
| EP-4536663-A1 | A PROCESS FOR PREPARING 1-[5-TERT-BUTYL-3-[(1-METHYLTETRAZOL-5 -YL)METHYL]TRIAZOLO[4,5-D]PYRIMIDIN-7-YL]PYRROLIDIN-3-OL | F. Hoffmann-La Roche AG (CH) | 2025-04-16 | — | — | EP | disclosed |
| WO-2025021868-A1 | TRAF2 INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER DISEASES | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2025-01-30 | — | — | WO | disclosed |
| CN-119325477-A | Process for the preparation of 1- [ 5-tert-butyl-3- [ (1-methyltetrazol-5-yl) methyl ] triazolo [4,5-d ] pyrimidin-7-yl ] pyrrolidin-3-ol | 豪夫迈·罗氏有限公司 | 2025-01-17 | — | — | CN | disclosed |
| US-12091425-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2024-09-17 | — | — | US | disclosed |
| EP-4423087-A1 | SYNTHESIS OF [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINES | F. Hoffmann-La Roche AG (CH) | 2024-09-04 | — | — | EP | disclosed |
| US-20240287084-A1 | SYNTHESIS OF [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINES | HOFFMANN-LA ROCHE INC. (US) | 2024-08-29 | — | — | US | disclosed |
| US-4616026-A | Antifungal 2-aryl-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)2-propanols | PFIZER INC. (US) | 1986-10-07 | — | — | US | disclosed |
| EP-0035046-B1 | NOVEL TETRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND ANTI-ULCER COMPOSITION CONTAINING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1985-10-02 | — | — | EP | disclosed |
| US-4540703-A | Tetrazole derivatives, anti-ulcer composition containing the same and method for treating ulcers | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1985-09-10 | — | — | US | disclosed |
| EP-0117100-A1 | Triazole antifungal agents | Pfizer Limited (GB) | 1984-08-29 | — | — | EP | disclosed |
| EP-0096296-A2 | 1-Sulfo-2-oxoazetidine derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-12-21 | — | — | EP | disclosed |
| US-4309428-A | Maytansinoids | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1982-01-05 | — | — | US | disclosed |
| EP-0035046-A1 | Novel tetrazole derivatives, process for the preparation thereof, and anti-ulcer composition containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1981-09-09 | — | — | EP | disclosed |
| EP-0025496-A1 | Maytansinoids, their production and therapeutic compositions containing them | Takeda Chemical Industries, Ltd. (JP) | 1981-03-25 | — | — | EP | disclosed |