Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTK | P29376 | 2/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | GRK5 | P34947 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | MST1R | Q04912 | 1/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL103370 | 0.98 | LTK (0.50) | LTKALKDYRK1BRETMET | |
| SCHEMBL31397701 | 0.96 | LTK (0.49) | LTKALKDYRK1BRETMET | |
| SCHEMBL18126808 | 0.73 | ALDH1A1 (0.43) | ADORA3KDM4EHSD17B10ALDH1A1NPC1 | |
| SCHEMBL1818352 | 0.73 | RET (0.50) | LTKALKDYRK1BRETMET | |
| SCHEMBL11032723 | 0.72 | LTK (0.41) | LTKALKDYRK1BRETMET | |
| SCHEMBL3519674 | 0.71 | KDM4E (0.50) | ADORA3KDM4EHSD17B10ALDH1A1NPC1 | |
| SCHEMBL18632535 | 0.71 | SCN5A (0.62) | LTKALKDYRK1BRETMET | |
| SCHEMBL12090712 | 0.69 | KDM4E (0.50) | KDM4EHSD17B10ALDH1A1GLAGAA | |
| SCHEMBL20772757 | 0.69 | PARP1 (0.42) | LTKALKDYRK1BRETMET | |
| SCHEMBL16439323 | 0.69 | CHEK1 (0.45) | LTKALKDYRK1BRETMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4465683-A | TRIAZOLOPYRIDINONES | MEAD JOHNSON & COMPANY (US) | 1984-08-14 | — | — | US | disclosed |
| EP-0025985-B1 | 2-SUBSTITUTED TRIAZOLO(4,3-1)PYRIDIN-3(2H)-ONES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DEPRESSION | Bristol-Myers Company (US) | 1983-11-23 | — | — | EP | disclosed |
| EP-0025603-B1 | TRIAZOLO (4,3-A)PYRIDIN-3(2H)-ONES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Bristol-Myers Company (US) | 1983-11-02 | — | — | EP | disclosed |
| EP-0025603-A1 | Triazolo (4,3-a)pyridin-3(2H)-ones, process for their preparation and pharmaceutical compositions containing them | Bristol-Myers Company (US) | 1981-03-25 | — | — | EP | disclosed |
| US-4254124-A | 2-(3-(4-(TRIFLUOROMETHYLPHENYL)-PIPERAZINO)-PROPYL)-S-TRIAZOLO(4,3 -A)PYRIDIN-3-ONE | MEAD JOHNSON & COMPANY (US) | 1981-03-03 | — | — | US | disclosed |