Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | USP8 | P40818 | 1/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340522 | 0.83 | KDM4E (0.49) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL7344946 | 0.82 | KDM4E (0.51) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL11071457 | 0.80 | KDM4E (0.46) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL7340095 | 0.80 | KDM4E (0.60) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL7335808 | 0.80 | KDM4E (0.64) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL11123162 | 0.78 | KDM4E (0.45) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL11075452 | 0.74 | KDM4E (0.49) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL11074845 | 0.72 | KDM4E (0.44) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL11073326 | 0.72 | KDM4E (0.44) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL11068699 | 0.71 | KDM4E (0.46) | KDM4EALDH1A1HPGDGAAGALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4474786-A | CONGESTIVE HEART FAILURE | SCHERING CORPORATION (US) | 1984-10-02 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |