Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | GALR3 | O60755 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 4/20 | 0.41 |
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | USP8 | P40818 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11067826 | 0.86 | KDM4E (0.44) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL11123162 | 0.80 | KDM4E (0.45) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL11075131 | 0.78 | MAOB (0.47) | KDM4EALDH1A1HPGDGAAMAOA | |
| SCHEMBL11071298 | 0.78 | MAOA (0.47) | KDM4EALDH1A1HPGDGAAMAOA | |
| SCHEMBL11073964 | 0.78 | MAOA (0.47) | KDM4EALDH1A1HPGDGAAMAOA | |
| SCHEMBL7340522 | 0.75 | KDM4E (0.49) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL11073229 | 0.75 | MAOA (0.44) | KDM4EALDH1A1HPGDGAAMAOA | |
| SCHEMBL11068819 | 0.75 | MAOA (0.44) | KDM4EALDH1A1HPGDGAAMAOA | |
| SCHEMBL11071902 | 0.75 | MAOA (0.44) | KDM4EALDH1A1HPGDGAAMAOA | |
| SCHEMBL11075452 | 0.75 | KDM4E (0.49) | KDM4EALDH1A1HPGDGAAGALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4474786-A | CONGESTIVE HEART FAILURE | SCHERING CORPORATION (US) | 1984-10-02 | — | — | US | claimed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | claimed |
| US-4474786-A | CONGESTIVE HEART FAILURE | SCHERING CORPORATION (US) | 1984-10-02 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |