Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11075966 | 1.00 | CYP2C9 (0.43) | CYP2C9MEN1KMT2AMAPK1MAPT | |
| SCHEMBL11076135 | 0.95 | CYP2C9 (0.42) | CYP2C9MEN1KMT2AMAPK1MAPT | |
| SCHEMBL11076133 | 0.95 | CYP2C9 (0.42) | CYP2C9MEN1KMT2AMAPK1MAPT | |
| SCHEMBL11070752 | 0.94 | SPHK1 (0.42) | CYP2C9MEN1KMT2AMAPK1MAPT | |
| SCHEMBL11070748 | 0.94 | SPHK1 (0.42) | CYP2C9MEN1KMT2AMAPK1MAPT | |
| SCHEMBL11066467 | 0.92 | MEN1 (0.42) | CYP2C9MEN1KMT2AMAPK1MAPT | |
| SCHEMBL11066471 | 0.92 | MEN1 (0.42) | CYP2C9MEN1KMT2AMAPK1MAPT | |
| SCHEMBL11073336 | 0.91 | MAPT (0.41) | CYP2C9MEN1KMT2AMAPK1MAPT | |
| SCHEMBL11073335 | 0.91 | MAPT (0.41) | CYP2C9MEN1KMT2AMAPK1MAPT | |
| SCHEMBL10579727 | 0.91 | CYP2C9 (0.41) | CYP2C9MEN1KMT2AMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4462923-A | Disubstituted pyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1984-07-31 | — | — | US | claimed |
| US-4462923-A | Disubstituted pyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1984-07-31 | — | — | US | disclosed |