Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 18/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13647878 | 0.89 | ADAM17 (0.70) | ADAM17MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL13648507 | 0.89 | ADAM17 (0.70) | ADAM17MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL8357654 | 0.88 | ADAM17 (1.00) | ADAM17 | |
| SCHEMBL2823324 | 0.82 | ATM (0.56) | ADAM17 | |
| SCHEMBL13648312 | 0.80 | ADAM17 (0.87) | ADAM17 | |
| SCHEMBL11078556 | 0.79 | ADAM17 (0.61) | ADAM17MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL11078559 | 0.79 | ADAM17 (0.61) | ADAM17MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL13648636 | 0.79 | ADAM17 (1.00) | ADAM17 | |
| SCHEMBL13648231 | 0.79 | ADAM17 (1.00) | ADAM17 | |
| SCHEMBL11075435 | 0.77 | ADAM17 (0.49) | ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4435419-A | Method of treating depression using azabicyclohexanes | AMERICAN CYANAMID COMPANY (US) | 1984-03-06 | — | — | US | disclosed |
| US-4231935-A | ANXIOLYTICS AND ANALGESICS | AMERICAN CYANAMID COMPANY (US) | 1980-11-04 | — | — | US | disclosed |
| US-4196120-A | 1,2-BIS(HYDROCARBYLSULFONYLOXY OR HALO METHYL)CYCLOPROPYLBENZENE, OPTICAL ACITIVITY ANALGESICS | AMERICAN CYANAMID COMPANY (US) | 1980-04-01 | — | — | US | disclosed |
| US-4131611-A | ANXIOLYTIC, ANALGESIC | AMERICAN CYANAMID COMPANY (US) | 1978-12-26 | — | — | US | disclosed |