Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | GLA | P06280 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11078482 | 0.72 | PDE3B (0.43) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL22717634 | 0.71 | DAO (0.57) | KDM4EGLAGAAALDH1A1PARP1 | |
| SCHEMBL15269600 | 0.71 | DAO (0.57) | KDM4EGLAGAAALDH1A1PARP1 | |
| SCHEMBL1680315 | 0.68 | KDM4E (0.47) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL4858672 | 0.68 | ALDH1A1 (0.72) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL1813746 | 0.68 | ALDH1A1 (0.72) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL7836288 | 0.67 | KDM4E (1.00) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL4860395 | 0.67 | ALDH1A1 (0.70) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL16238134 | 0.67 | ALDH1A1 (0.70) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL10134618 | 0.66 | PARP1 (0.70) | KDM4EGLAGAAALDH1A1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4474786-A | CONGESTIVE HEART FAILURE | SCHERING CORPORATION (US) | 1984-10-02 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |