Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 2/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.40 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5502468 | 0.83 | GABBR2 (0.46) | DPP4TAAR1IDO1TDO2LOXL2 | |
| SCHEMBL18466458 | 0.83 | GABBR2 (0.46) | DPP4TAAR1IDO1TDO2LOXL2 | |
| SCHEMBL3406829 | 0.82 | SLC2A1 (0.42) | DPP4IDO1TDO2LOXL2DPP8 | |
| SCHEMBL27387510 | 0.82 | IDO1 (0.40) | DPP4IDO1TDO2LOXL2DPP8 | |
| SCHEMBL1762072 | 0.82 | SLC2A1 (0.42) | DPP4IDO1TDO2LOXL2DPP8 | |
| SCHEMBL3338459 | 0.82 | IDO1 (0.40) | DPP4IDO1TDO2LOXL2DPP8 | |
| SCHEMBL971562 | 0.82 | IDO1 (0.40) | DPP4IDO1TDO2LOXL2DPP8 | |
| SCHEMBL971560 | 0.82 | IDO1 (0.40) | DPP4IDO1TDO2LOXL2DPP8 | |
| SCHEMBL27718785 | 0.82 | DPP4 (0.42) | DPP4TAAR1IDO1TDO2LOXL2 | |
| SCHEMBL4618800 | 0.81 | HRH1 (0.62) | TAAR1IDO1TDO2LOXL2GABBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4322421-A | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4261995-A | DISORDERS OF CENTRAL NERVOUS SYSTEM AND CARDIOVASCULAR SYSTEM; HYPOTENSIVE | SYNTEX (U.S.A.) INC. (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |