GABBR2

Gamma-aminobutyric acid type B receptor subunit 2 · O75899 · GABBR2 on Sugi Atlas →

20,368 patent compounds predicted against GABBR2, 11,256 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Baclofen (SCHEMBL19333)	1.00	8/20
Baclofen (SCHEMBL19334)	1.00	8/20
Arbaclofen (SCHEMBL351220)	1.00	8/20
SCHEMBL349306	0.56	8/20
Phaclofen (SCHEMBL339995)	0.57	7/20
SCHEMBL351660	0.57	7/20
SCHEMBL339757	1.00	6/20
SCHEMBL339758	1.00	6/20
Phenibut (SCHEMBL340838)	1.00	6/20
SCHEMBL342399	1.00	6/20
Phenibut (SCHEMBL351501)	1.00	6/20
SCHEMBL351502	0.70	6/20
SCHEMBL351702	0.70	6/20
SCHEMBL523877	0.59	6/20
Hydrochloric Acid (SCHEMBL191270)	0.56	6/20
Hydrochloric Acid (SCHEMBL191271)	0.56	6/20
SCHEMBL342850	0.56	6/20
SCHEMBL341755	0.56	6/20
SCHEMBL296405	0.53	6/20
4-Amino-3- (5-Chlorothien-2-Yl)Butanoic Acid (SCHEMBL342009)	1.00	5/20

Clinical trials — most relevant to GABBR2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Computational Assessment of GABA Receptor Modulation in PTSD	PHASE4	RECRUITING
Evaluating the Safety of Acute Baclofen in Methadone-maintained Individuals With Opiate Dependence.	PHASE4	COMPLETED
The Effect of Oral Baclofen and Botulinum Toxin Treatments in Hemiplegic Spasticity on the Nociceptive Flexor Reflex	PHASE4	COMPLETED
Safety of Ramelteon in Elderly Subjects	PHASE4	COMPLETED
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia	PHASE3	COMPLETED
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD	PHASE3	COMPLETED
Safety and Efficacy of Ramelteon and Doxepin in Subjects With Chronic Insomnia	PHASE2	COMPLETED
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia	PHASE2	COMPLETED
Diazepam Trial in GAD65 Associated Epilepsy	PHASE1/PHASE2	WITHDRAWN
Effects of Baclofen on Presynaptic Inhibition in Humans	PHASE2	WITHDRAWN
PET Imaging of Brain Peripheral Benzodiazepine Receptors	PHASE1	COMPLETED
PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28	PHASE1	COMPLETED
MEG Study of Acute STX209 Effects in ASD	EARLY_PHASE1	COMPLETED
Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression	EARLY_PHASE1	RECRUITING
Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T	EARLY_PHASE1	UNKNOWN
GABA Biomarkers in Dravet Syndrome	nan	RECRUITING
Brain Changes in Patients With Focal Hand Dystonia	nan	COMPLETED
Cenobamate Efficacy in Individuals With Autoimmune Epilepsy	nan	ENROLLING_BY_INVITATION
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy	nan	UNKNOWN
Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk	nan	COMPLETED
Protocol Assessment of Motor Cortex rTMS for Treating Neuropathic Pain	nan	RECRUITING
The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Working Memory	nan	COMPLETED
Butyrate Supplementation in Children With Autism Spectrum Disorder (ASD) and Functional Gastrointestinal Disorders	nan	RECRUITING
Effect of Gabapentin on GABA Concentration and Emotional Processing	nan	COMPLETED
Assessment of Peripheral GABA Receptors for Local Pain Relief	nan	UNKNOWN
Study of GABA-A Receptors in the Generation of Tics in Patients With Tourette's Syndrome	nan	COMPLETED
Clinical-Genetic Variation in GABA/Alcohol Sensitivity	nan	COMPLETED
Pilot Study Evaluating Neuro-Imaging Correlates of Epigenetic Finding in Prediction of Chronic Postsurgical Pain	nan	UNKNOWN
Cryoneurolysis for Spasticity Treatment: Long-term Clinical Outcomes and Mechanisms in the Central Nervous System	nan	RECRUITING
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery.	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GABBR2 binder may also engage these)

Protein	Name	Similarity
Q80T41	—	1.000	Q80T41 →
O88871	—	1.000	O88871 →
G5ECB2	—	0.996	G5ECB2 →
P23385	—	0.993	P23385 →
Q09630	—	0.992	Q09630 →
Q7JQ32	—	0.990	Q7JQ32 →
Q23681	—	0.990	Q23681 →
H2L0Q3	—	0.990	H2L0Q3 →
A8WPG9	—	0.990	A8WPG9 →
O16544	—	0.989	O16544 →
Q61056	—	0.989	Q61056 →
O94910	—	0.989	O94910 →
Q6TL19	—	0.988	Q6TL19 →
G5ECQ2	—	0.988	G5ECQ2 →
O88923	—	0.988	O88923 →
Q9GYQ4	—	0.988	Q9GYQ4 →
CASR	Extracellular calcium-sensing receptor	0.988	landscape →
P31424	—	0.988	P31424 →
Q60934	—	0.988	Q60934 →
GRIK4	Glutamate receptor ionotropic, kainate 4 (Glu	0.987	landscape →
P19334	—	0.987	P19334 →
A3QM97	—	0.987	A3QM97 →
Q63118	—	0.987	Q63118 →
Q3UVX5	—	0.987	Q3UVX5 →
O62714	—	0.987	O62714 →
O62852	—	0.986	O62852 →
O97831	—	0.986	O97831 →
Q9QYS2	—	0.986	Q9QYS2 →
Q9PW88	—	0.986	Q9PW88 →
E9PU17	—	0.986	E9PU17 →