Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | EBP | Q15125 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11087206 | 0.86 | POLB (0.46) | POLBL3MBTL1MEN1KMT2AKCNH2 | |
| SCHEMBL9016232 | 0.79 | KCNH2 (0.54) | POLBL3MBTL1MEN1KMT2AKCNH2 | |
| SCHEMBL9016222 | 0.78 | KCNH2 (0.61) | POLBL3MBTL1MEN1KMT2AKCNH2 | |
| SCHEMBL9016218 | 0.78 | POLB (0.55) | POLBL3MBTL1MEN1KMT2AHTR2A | |
| SCHEMBL9016240 | 0.78 | MEN1 (0.58) | POLBL3MBTL1MEN1KMT2AKCNH2 | |
| SCHEMBL9016214 | 0.78 | KCNH2 (0.54) | POLBL3MBTL1MEN1KMT2AKCNH2 | |
| Methyl Alcohol SCHEMBL11168025 | 0.77 | MEN1 (0.56) | POLBL3MBTL1MEN1KMT2AKCNH2 | |
| SCHEMBL9016247 | 0.76 | POLB (0.49) | POLBL3MBTL1MEN1KMT2AKCNH2 | |
| SCHEMBL11080480 | 0.76 | POLB (0.50) | POLBL3MBTL1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL9016258 | 0.75 | KCNH2 (0.52) | MEN1KMT2AKCNH2HTR2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4438116-A | Quinoxalinyloxy-amino-propanol compounds with blood pressure lowering and β-blocking properties, their use and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1984-03-20 | — | — | US | disclosed |
| EP-0019918-A1 | Derivatives of amino-propanol, processes for preparing them and pharmaceutical compositions containing them | Roche Diagnostics GmbH (DE) | 1980-12-10 | — | — | EP | disclosed |