Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | TDO2 | P48775 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9883145 | 0.88 | SLC6A2 (0.46) | IDO1TDO2SLC6A2SLC6A4TAAR1 | |
| SCHEMBL7538162 | 0.85 | SLC6A2 (0.43) | IDO1TDO2SLC6A2SLC6A4TAAR1 | |
| SCHEMBL2628025 | 0.85 | SLC6A2 (0.43) | IDO1TDO2SLC6A2SLC6A4TAAR1 | |
| SCHEMBL9880968 | 0.85 | SLC6A2 (0.43) | IDO1TDO2SLC6A2SLC6A4TAAR1 | |
| SCHEMBL11283326 | 0.84 | SLC6A2 (0.47) | SLC6A2SLC6A4TAAR1AOC3 | |
| SCHEMBL6000664 | 0.83 | TAAR1 (0.56) | IDO1TDO2SLC6A2SLC6A4TAAR1 | |
| SCHEMBL3043788 | 0.81 | IDO1 (0.46) | IDO1TDO2SLC6A2SLC6A4TAAR1 | |
| SCHEMBL8244458 | 0.81 | IDO1 (0.46) | IDO1TDO2SLC6A2SLC6A4TAAR1 | |
| SCHEMBL9902786 | 0.81 | IDO1 (0.46) | IDO1TDO2SLC6A2SLC6A4TAAR1 | |
| SCHEMBL3490337 | 0.79 | PNMT (0.61) | SLC6A2SLC6A4TAAR1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4322421-A | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4261995-A | DISORDERS OF CENTRAL NERVOUS SYSTEM AND CARDIOVASCULAR SYSTEM; HYPOTENSIVE | SYNTEX (U.S.A.) INC. (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |