PNMT

Phenylethanolamine N-methyltransferase · P11086 · PNMT on Sugi Atlas →

39,132 patent compounds predicted against PNMT, 18,335 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Hydrochloric Acid (SCHEMBL158709)	0.96	14/20
SCHEMBL324460	1.00	12/20
Hydrochloric Acid (SCHEMBL325622)	0.97	12/20
SCHEMBL329957	0.69	12/20
SCHEMBL383577	0.74	11/20
Trifluoroacetic Acid (SCHEMBL384591)	0.57	11/20
SCHEMBL476330	1.00	10/20
Hydrochloric Acid (SCHEMBL366688)	0.95	9/20
SCHEMBL330080	0.60	9/20
SCHEMBL444913	0.56	9/20
SCHEMBL417912	0.54	9/20
SCHEMBL419456	0.48	9/20
SCHEMBL419457	0.48	9/20
SCHEMBL330686	0.75	8/20
SCHEMBL257552	0.61	8/20
SCHEMBL184089	0.61	8/20
Hydrochloric Acid (SCHEMBL184033)	0.59	8/20
SCHEMBL396834	0.51	8/20
SCHEMBL351435	1.00	7/20
Hydrochloric Acid (SCHEMBL65520)	0.96	7/20

Clinical trials — most relevant to PNMT by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Trial of CM-AT in Children With Autism With All Levels of FCT (The Blum Study)	PHASE3	COMPLETED
Modafinil vs Placebo for the Treatment of Methamphetamine Dependence	PHASE2	COMPLETED
Monoamine Antagonist Therapies for Methamphetamine Abuse Prazosin	PHASE2	COMPLETED
PET Imaging of Dopamine in Healthy Study Participants	PHASE2	COMPLETED
Cilostazol in Parkinson's Disease	PHASE2	NOT_YET_RECRUITING
Clinical, Neurocognitive, and Emotional Effects of Psilocybin in Depressed Patients - Proof of Concept	PHASE2	COMPLETED
Role of the Catechol-O-methyltransferase (COMT) in the Physiological Regulation of Vigilance	PHASE1	COMPLETED
Acute Dose-dependent Effects of DMT in Healthy Subjects	PHASE1	COMPLETED
Effects of Modafinil on Brain Function in Patients With Schizophrenia	PHASE1	COMPLETED
Investigation of Psychedelic Effects in Psychoactive Substances	PHASE1	RECRUITING
Acute Analgesic Effects of DMT on Experimentally Induced Pain in Healthy Participants	PHASE1	COMPLETED
Acute Dose-dependent Effects of DMT-bolus Applications in Healthy Subjects (DMT BDR-Study)	PHASE1	COMPLETED
Psilocybin Brain Stimulation and Imaging Pilot Study	PHASE1	ACTIVE_NOT_RECRUITING
Human Requirements for the Nutrient Choline	nan	COMPLETED
Neural Response to Catecholamine Depletion in Subjects Suffering From Bulimia Nervosa in Their Past and Healthy Controls	nan	SUSPENDED
Estrogen Receptor 1 Gene Polymorphism Frequency in Fibromyalgia Syndrome	nan	COMPLETED
Vancomycin Associated Red Man Syndrome (RMS)	nan	COMPLETED
In Vivo Assessment of Histamine Pharmacodynamics	nan	WITHDRAWN
Effects of Photobiomodulation Therapy Combined With Static Magnetic Field in Patients With Lateral Epicondylitis	nan	COMPLETED
Melatonin in Pregnancy	nan	COMPLETED
Sympathetic Activity and Cardiometabolic Complications	nan	COMPLETED
Choline Dose Ranging in Postmenopausal Women	nan	COMPLETED
Hodgkin's Disease and Chemotherapy Before 40 Years	nan	NOT_YET_RECRUITING
Prevalence of New Psychoactive Substances Use	nan	UNKNOWN
Investigation of Serotonin Neurotransmission in MDMA Users Using Combinated Dexfenfluramine Challenge and PET Imaging	nan	COMPLETED
Effects of Photobiomodulation Therapy Combined With Static Magnetic Field in CrossFit® Athletes	nan	COMPLETED
The Role of Sex Steroids and Serotonin Brain Dynamics in Perinatal Mental Health	nan	COMPLETED
Pharmacogenetic and Neurofunctional Brain Areas Study in Obese Patients With Binge Eating Disorder	nan	UNKNOWN
Neurobiological Mechanisms in Panic Disorder	nan	COMPLETED
Exploration of Glutamatergic System With PET Radiotracer in Gilles de la Tourette Patients: Pilot Study (GlutaTour)	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a PNMT binder may also engage these)

Protein	Name	Similarity
P10937	—	0.998	P10937 →
A0A5F8AH41	—	0.996	A0A5F8AH41 →
P10938	—	0.996	P10938 →
Q5RFR7	—	0.991	Q5RFR7 →
P40935	—	0.990	P40935 →
P40936	—	0.990	P40936 →
Q5JTZ9	—	0.987	Q5JTZ9 →
O97972	—	0.987	O97972 →
Q06AU9	—	0.985	Q06AU9 →
O55171	—	0.984	O55171 →
P0DPD7	—	0.984	P0DPD7 →
INMT	Indolethylamine N-methyltransferase	0.983	landscape →
P0DPE1	—	0.983	P0DPE1 →
Q8VDP3	—	0.982	Q8VDP3 →
Q149M9	—	0.982	Q149M9 →
O43542	—	0.982	O43542 →
Q5RCH4	—	0.981	Q5RCH4 →
Q6NTR1	—	0.981	Q6NTR1 →
P0DPE0	—	0.981	P0DPE0 →
D3ZBP4	—	0.980	D3ZBP4 →
Q2V057	—	0.980	Q2V057 →
Q9HCU5	—	0.980	Q9HCU5 →
TARS2	Threonine--tRNA ligase, mitochondrial	0.980	landscape →
Q643R3	—	0.980	Q643R3 →
Q3URQ7	—	0.980	Q3URQ7 →
A0AVI4	—	0.980	A0AVI4 →
NNMT	Nicotinamide N-methyltransferase	0.979	landscape →
A9ULG4	—	0.979	A9ULG4 →
Q8CGS5	—	0.979	Q8CGS5 →
O55137	—	0.979	O55137 →