Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6631073 | 0.87 | HTT (0.46) | HTTSMN1; SMN2LMNAKMT2ACYP1A2 | |
| SCHEMBL2632758 | 0.84 | HTT (0.44) | HTTSMN1; SMN2LMNAKMT2ACYP1A2 | |
| SCHEMBL29826849 | 0.84 | HTT (0.44) | HTTSMN1; SMN2LMNAKMT2ACYP1A2 | |
| SCHEMBL22655940 | 0.82 | HTT (0.43) | HTTSMN1; SMN2LMNAKMT2ACYP1A2 | |
| SCHEMBL379234 | 0.82 | HTT (0.34) | HTTSMN1; SMN2KMT2AMAPK1NPC1 | |
| SCHEMBL1671889 | 0.80 | HTT (0.42) | HTTSMN1; SMN2LMNAKMT2ACYP1A2 | |
| SCHEMBL18614528 | 0.79 | HTT (0.41) | HTTSMN1; SMN2LMNAKMT2ACYP1A2 | |
| SCHEMBL13020600 | 0.79 | HTT (0.41) | HTTSMN1; SMN2LMNAKMT2ACYP1A2 | |
| SCHEMBL8901362 | 0.77 | HTT (0.39) | HTTSMN1; SMN2LMNAKMT2AALDH1A1 | |
| SCHEMBL3281802 | 0.77 | HTT (0.40) | HTTSMN1; SMN2LMNAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-57091992-A | — | — | None | — | — | JP | disclosed |
| CN-116354936-A | Novel heterocyclic compounds useful as selective AURORA a inhibitors | 北京加科思新药研发有限公司 | 2023-06-30 | — | — | CN | disclosed |
| US-20230128198-A1 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL AS AURORA A SELECTIVE INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD (CN) | 2023-04-27 | — | — | US | disclosed |
| US-20230128198-A1 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL AS AURORA A SELECTIVE INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD (CN) | 2023-04-27 | — | — | US | disclosed |
| US-20230128198-A1 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL AS AURORA A SELECTIVE INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD (CN) | 2023-04-27 | — | — | US | disclosed |
| CN-114423751-B | Novel heterocyclic compounds useful as selective AURORA a inhibitors | 北京加科思新药研发有限公司 | 2023-04-21 | — | — | CN | disclosed |
| EP-4093736-A1 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL AS AURORA A SELECTIVE INHIBITORS | Jacobio Pharmaceuticals Co., Ltd. (CN) | 2022-11-30 | — | — | EP | disclosed |
| US-11384066-B1 | Heterocyclic compounds useful as aurora a selective inhibitors | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-07-12 | — | — | US | disclosed |
| US-11384066-B1 | Heterocyclic compounds useful as aurora a selective inhibitors | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-07-12 | — | — | US | disclosed |
| CN-114423751-A | Novel heterocyclic compounds useful as selective AURORA a inhibitors | 北京加科思新药研发有限公司 | 2022-04-29 | — | — | CN | disclosed |
| WO-2021147974-A1 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL AS AURORA A SELECTIVE INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2021-07-29 | — | — | WO | disclosed |
| EP-0015078-B1 | ORGANO-PHOSPHORIC ESTERS, THEIR PRODUCTION AND USE AS PESTICIDES, AS WELL AS THE INTERMEDIATES THEREOF AND THEIR PRODUCTION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1984-07-04 | — | — | EP | disclosed |
| JP-S5791992-A | PYRIMIDINE, ITS PREPARATION AND INSECTICIDE, ACARICIDE AND NEMATOCIDE CONTAINING THE SAME AS ACTIVE CONSTITUENT | SUMITOMO CHEM CO LTD | 1982-06-08 | — | — | JP | disclosed |
| US-4326058-A | INSECTICIDE, ACARICIDE, AND NEMATOCIDE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-04-20 | — | — | US | disclosed |
| EP-0015078-A2 | Organo-phosphoric esters, their production and use as pesticides, as well as the intermediates thereof and their production | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1980-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11384066-B1 | Heterocyclic compounds useful as aurora a selective inhibitors | AURKA, AURKC, AURKB | HTT 4306/4885SMN1; SMN2 4401/4885LMNA 1009/4885 |
| US-20230128198-A1 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL AS AURORA A SELECTIVE INHIBITORS | AURKA, AURKC, AURKB | HTT 4284/4885SMN1; SMN2 4569/4885LMNA 1226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.