Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 3/20 | 0.31 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.30 |
| ▸ | ALPL | P05186 | 1/20 | 0.30 |
| ▸ | ALPG | P10696 | 1/20 | 0.30 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6631073 | 0.84 | HTT (0.46) | HTTSMN1; SMN2KMT2AMAPTGAA | |
| SCHEMBL2117448 | 0.84 | — | — | |
| SCHEMBL4288745 | 0.80 | HTT (0.41) | HTTKDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL3861126 | 0.78 | MAPT (0.41) | HTTKDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL9252957 | 0.78 | HTT (0.44) | HTTKDM4EALDH1A1KMT2AGAA | |
| SCHEMBL11077413 | 0.77 | HTT (0.50) | HTTSMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL9843905 | 0.77 | HTT (0.38) | HTTALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL11362095 | 0.76 | SMN1; SMN2 (0.34) | SMN1; SMN2KMT2A | |
| SCHEMBL11346997 | 0.75 | HTT (0.37) | HTTKDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL11334859 | 0.75 | HTT (0.37) | HTTKDM4EALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116354936-A | Novel heterocyclic compounds useful as selective AURORA a inhibitors | 北京加科思新药研发有限公司 | 2023-06-30 | — | — | CN | disclosed |
| CN-114423751-B | Novel heterocyclic compounds useful as selective AURORA a inhibitors | 北京加科思新药研发有限公司 | 2023-04-21 | — | — | CN | disclosed |
| EP-4093736-A1 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL AS AURORA A SELECTIVE INHIBITORS | Jacobio Pharmaceuticals Co., Ltd. (CN) | 2022-11-30 | — | — | EP | disclosed |
| CN-114423751-A | Novel heterocyclic compounds useful as selective AURORA a inhibitors | 北京加科思新药研发有限公司 | 2022-04-29 | — | — | CN | disclosed |
| WO-2021147974-A1 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL AS AURORA A SELECTIVE INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2021-07-29 | — | — | WO | disclosed |
| WO-1997038995-A1 | FUNGICIDAL OXAZOLIDINEDIONE DERIVATIVES | ZENECA LIMITED (GB) | 1997-10-23 | — | — | WO | disclosed |
| EP-0015078-B1 | ORGANO-PHOSPHORIC ESTERS, THEIR PRODUCTION AND USE AS PESTICIDES, AS WELL AS THE INTERMEDIATES THEREOF AND THEIR PRODUCTION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1984-07-04 | — | — | EP | disclosed |
| US-4326058-A | INSECTICIDE, ACARICIDE, AND NEMATOCIDE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-04-20 | — | — | US | disclosed |
| EP-0002200-B1 | N,N-DIALKYL-O-PYRIMIDINYL-CARBAMIC ACID ESTERS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS INSECTICIDES | BAYER AG (DE) | 1981-09-02 | — | — | EP | disclosed |
| EP-0015078-A2 | Organo-phosphoric esters, their production and use as pesticides, as well as the intermediates thereof and their production | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1980-09-03 | — | — | EP | disclosed |
| US-4200637-A | Combating arthropods with N,N-dialkyl-O-(2-substituted-methyl-pyrimidin-4-yl)-carbamic acid esters | BAYER AKTIENGESELLSCHAFT (DE) | 1980-04-29 | — | — | US | disclosed |
| EP-0002200-A1 | N,N-dialkyl-O-pyrimidinyl-carbamic acid esters, process for their preparation, and their use as insecticides | BAYER AG (DE) | 1979-06-13 | — | — | EP | disclosed |
| EP-0001602-A1 | Substituted pyrimidinyl(thiono)(thiol)phosphoric(phosphonic) acid esters and ester amides, process for their preparation and their use as insecticides and acaricides | BAYER AG (DE) | 1979-05-02 | — | — | EP | disclosed |