Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | DRD3 | P35462 | 4/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11075002 | 0.90 | HTR1D (0.36) | OPRM1OPRL1HTR1AHTR1D | |
| SCHEMBL11076134 | 0.86 | HTR1D (0.38) | OPRM1OPRL1HTR1AHTR1D | |
| SCHEMBL11076865 | 0.79 | HTR1D (0.36) | HTR1ADRD2DRD3HTR1D | |
| SCHEMBL11075507 | 0.78 | HTR1D (0.39) | HTR1ADRD2DRD3HTR1DSLC6A4 | |
| SCHEMBL11067219 | 0.78 | HTR1D (0.38) | HTR1ADRD2DRD3HTR1DSLC6A4 | |
| SCHEMBL11070194 | 0.77 | HTR1D (0.37) | HTR1ADRD2DRD3HTR1DSLC6A4 | |
| SCHEMBL11076941 | 0.76 | HTR1D (0.40) | OPRM1HTR1ADRD2DRD3DRD4 | |
| SCHEMBL11076146 | 0.76 | HTR1D (0.36) | OPRM1OPRL1HTR1ADRD2DRD3 | |
| SCHEMBL11070143 | 0.76 | OPRL1 (0.56) | OPRM1OPRL1SLC6A4SLC6A3 | |
| SCHEMBL11076041 | 0.75 | BCHE (0.44) | OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4447454-A | Analgetic compounds, compositions and process of treatment | THE UPJOHN COMPANY (US) | 1984-05-08 | — | — | US | disclosed |
| US-4113866-A | ANALGETIC COMPOUNDS, COMPOSITIONS AND PROCESS OF TREATMENT | THE UPJOHN COMPANY (US) | 1978-09-12 | — | — | US | disclosed |