Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 12/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10561229 | 0.70 | SLC6A4 (0.52) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 | |
| SCHEMBL10561232 | 0.69 | EGLN1 (0.43) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL5308100 | 0.68 | SLC6A4 (0.51) | SLC6A4SLC6A3SLC6A2KCNH2 | |
| SCHEMBL7705208 | 0.63 | — | — | |
| SCHEMBL5164447 | 0.62 | SLC6A4 (0.47) | SLC6A4SLC6A3SLC6A2KCNH2OPRM1 | |
| SCHEMBL15392373 | 0.61 | MAPK9 (0.48) | — | |
| Bromide SCHEMBL18240063 | 0.60 | MAPK9 (0.47) | — | |
| SCHEMBL7366815 | 0.60 | HDAC1 (0.50) | SLC6A4SLC6A3SLC6A2KCNH2OPRM1 | |
| SCHEMBL5164903 | 0.60 | SLC6A4 (0.44) | SLC6A4SLC6A3SLC6A2KCNH2OPRM1 | |
| SCHEMBL5167951 | 0.60 | SLC6A4 (0.44) | SLC6A4SLC6A3SLC6A2KCNH2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0108488-A1 | (1-Arylcyclobutyl) (heterocyclyl) methylamine compounds, their preparation and their use as therapeutic agents | The Boots Company PLC (GB) | 1984-05-16 | — | — | EP | disclosed |