Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.32 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.32 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11082787 | 0.88 | TLR8 (0.39) | BRD4ADRA2AADRA2BADRA2CTSHR | |
| SCHEMBL11078618 | 0.85 | BRD4 (0.35) | BRD4ADRA2AADRA1ASLC22A2HTR1A | |
| SCHEMBL11088778 | 0.80 | BRD4 (0.38) | BRD4ADRA2AADRA1AADRA2BADRA2C | |
| SCHEMBL11080571 | 0.77 | HTR2C (0.40) | BRD4ADRA2AADRA1ASLC22A2HTR1A | |
| SCHEMBL11077345 | 0.76 | HTR2A (0.43) | HSD17B10 | |
| SCHEMBL11083189 | 0.76 | ADRA1A (0.40) | BRD4ADRA2AADRA1AADRA1DADRA1B | |
| SCHEMBL11110304 | 0.76 | BRD4 (0.57) | BRD4ADRA2AADRA1ASLC22A2HTR1A | |
| SCHEMBL11082926 | 0.76 | ADRA1A (0.40) | BRD4ADRA2AADRA1AADRA1DADRA1B | |
| SCHEMBL11078778 | 0.76 | BRD4 (0.37) | BRD4ADRA2AADRA1ASLC22A2HTR1A | |
| SCHEMBL11286631 | 0.76 | HSD17B10 (0.31) | ADRA2AADRA1AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |