Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Indecainide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MTTP | P55157 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indecainide SCHEMBL121202 | 0.96 | KDM4E (0.42) | KDM4EALDH1A1TDP1APEX1 | |
| Indecainide SCHEMBL11086669 | 0.95 | KDM4E (0.41) | KDM4EALDH1A1TDP1APEX1MTTP | |
| Indecainide SCHEMBL121201 | 0.95 | KDM4E (0.41) | KDM4EALDH1A1TDP1APEX1 | |
| Indecainide SCHEMBL29397898 | 0.95 | KDM4E (0.41) | KDM4EALDH1A1TDP1APEX1 | |
| Indecainide SCHEMBL1649456 | 0.94 | KDM4E (0.41) | KDM4EALDH1A1TDP1APEX1MTTP | |
| SCHEMBL11090876 | 0.82 | KDM4E (0.41) | KDM4EALDH1A1TDP1MTTP | |
| SCHEMBL10995584 | 0.81 | APEX1 (0.40) | TDP1APEX1THRBMTTP | |
| Hydrochloric Acid SCHEMBL11090502 | 0.81 | KDM4E (0.41) | KDM4EALDH1A1TDP1MTTP | |
| SCHEMBL11092008 | 0.81 | KDM4E (0.41) | KDM4EALDH1A1TDP1APEX1MTTP | |
| Acetic Acid SCHEMBL10775934 | 0.80 | MTTP (0.38) | KDM4EALDH1A1APEX1MTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452745-A | ANTIARRHYTHMIA AGENTS | ELI LILLY AND COMPANY (US) | 1984-06-05 | — | — | US | disclosed |
| EP-0018076-B1 | 9-AMINOALKYLFLUORENES, PROCESS THEREFOR AND ANTIARRHYTHMIC FORMULATIONS THEREOF | ELI LILLY AND COMPANY (US) | 1983-09-21 | — | — | EP | disclosed |
| US-4382093-A | 9-Aminoalkylfluorenes | ELI LILLY AND COMPANY (US) | 1983-05-03 | — | — | US | disclosed |
| US-4277495-A | FLUORENE 9-AMINOALKYL-9-CARBOXYLIC ACIDS OR ESTERS | ELI LILLY AND COMPANY (US) | 1981-07-07 | — | — | US | disclosed |
| EP-0018076-A1 | 9-Aminoalkylfluorenes, process therefor and antiarrhythmic formulations thereof | ELI LILLY AND COMPANY (US) | 1980-10-29 | — | — | EP | disclosed |