Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | MTTP | P55157 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indecainide SCHEMBL121202 | 0.84 | KDM4E (0.42) | KDM4EALDH1A1TDP1APEX1 | |
| SCHEMBL11090876 | 0.83 | KDM4E (0.41) | KDM4EALDH1A1TDP1MTTP | |
| Indecainide SCHEMBL11086669 | 0.83 | KDM4E (0.41) | KDM4EALDH1A1TDP1APEX1MTTP | |
| Indecainide SCHEMBL29397898 | 0.83 | KDM4E (0.41) | KDM4EALDH1A1TDP1APEX1 | |
| Indecainide SCHEMBL121201 | 0.83 | KDM4E (0.41) | KDM4EALDH1A1TDP1APEX1 | |
| Hydrochloric Acid SCHEMBL11090502 | 0.82 | KDM4E (0.41) | KDM4EALDH1A1TDP1MTTP | |
| Indecainide SCHEMBL1649456 | 0.82 | KDM4E (0.41) | KDM4EALDH1A1TDP1APEX1MTTP | |
| Indecainide SCHEMBL11078673 | 0.81 | KDM4E (0.43) | KDM4EALDH1A1TDP1APEX1MTTP | |
| SCHEMBL11091509 | 0.80 | ALDH1A1 (0.42) | KDM4EALDH1A1TDP1MTTP | |
| SCHEMBL11478909 | 0.77 | MTTP (0.44) | KDM4EALDH1A1MTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0038676-B1 | PROCESS FOR PREPARING FLUORENE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1984-10-17 | — | — | EP | disclosed |
| US-4452745-A | ANTIARRHYTHMIA AGENTS | ELI LILLY AND COMPANY (US) | 1984-06-05 | — | — | US | disclosed |
| US-4382093-A | 9-Aminoalkylfluorenes | ELI LILLY AND COMPANY (US) | 1983-05-03 | — | — | US | disclosed |
| EP-0038676-A1 | Process for preparing fluorene derivatives | ELI LILLY AND COMPANY (US) | 1981-10-28 | — | — | EP | disclosed |
| US-4282170-A | CHEMICAL INTERMEDIATES 9-AMINOALKYL-9-CARBAMOYL-FLUORENES | ELI LILLY AND COMPANY (US) | 1981-08-04 | — | — | US | disclosed |
| US-4277495-A | FLUORENE 9-AMINOALKYL-9-CARBOXYLIC ACIDS OR ESTERS | ELI LILLY AND COMPANY (US) | 1981-07-07 | — | — | US | disclosed |