Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11070412 | 0.98 | MAPT (0.42) | MAPTABCB11LMNAMAPK1TDP1 | |
| SCHEMBL11073072 | 0.98 | MAPT (0.42) | MAPTABCB11LMNAMAPK1TDP1 | |
| SCHEMBL11077258 | 0.91 | MAPT (0.47) | MAPTABCB11LMNAMAPK1TDP1 | |
| SCHEMBL11067568 | 0.90 | MAPT (0.46) | MAPTABCB11LMNAMAPK1ATM | |
| SCHEMBL11076786 | 0.90 | MAPT (0.46) | MAPTABCB11LMNAMAPK1ATM | |
| SCHEMBL11073407 | 0.90 | ABCB11 (0.49) | MAPTABCB11LMNAMAPK1TDP1 | |
| SCHEMBL11075060 | 0.90 | MAPT (0.46) | MAPTABCB11LMNAMAPK1ATM | |
| SCHEMBL11070127 | 0.90 | MAPT (0.46) | MAPTABCB11LMNAMAPK1ATM | |
| SCHEMBL11080655 | 0.90 | MAPT (0.46) | MAPTABCB11LMNAMAPK1ATM | |
| SCHEMBL11076754 | 0.88 | ABCB11 (0.51) | MAPTABCB11LMNAMAPK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4430339-A | PROPHYLAXIS, METABOLISM, GLUCOSE, FATS, HYPOGLYCEMIC AGENTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-02-07 | — | — | US | disclosed |
| WO-1982000822-A1 | SUBSTITUTED OXIRANECARBOXYLIC ACIDS,THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | EISTETTER K | 1982-03-18 | — | — | WO | disclosed |