Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 3/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 4/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27965965 | 0.83 | NQO2 (0.44) | BRD4JAK2KITJAK3MAP4K2 | |
| SCHEMBL27965887 | 0.83 | BRD4 (0.43) | BRD4JAK2KITJAK3MAP4K2 | |
| SCHEMBL27965792 | 0.80 | CYP19A1 (0.41) | BRD4JAK2KITJAK3MAP4K2 | |
| SCHEMBL3078111 | 0.79 | JAK2 (0.53) | BRD4JAK2KITJAK3MAP4K2 | |
| SCHEMBL30564910 | 0.79 | JAK2 (0.53) | BRD4JAK2KITJAK3MAP4K2 | |
| SCHEMBL29242303 | 0.72 | BRD4 (0.47) | BRD4MEN1KMT2AKDM4E | |
| SCHEMBL30965336 | 0.72 | BRD4 (0.47) | BRD4MEN1KMT2AKDM4E | |
| SCHEMBL6381012 | 0.70 | KDM4E (0.48) | JAK2KITJAK3MAP4K2ALK | |
| SCHEMBL9580444 | 0.70 | KMT2A (0.46) | BRD4JAK2KITJAK3MAP4K2 | |
| SCHEMBL325218 | 0.68 | HAO1 (0.53) | BRD4HAO1MEN1KMT2AKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4450266-A | STABILIZERS | BAYER AKTIENGESELLSCHAFT (DE) | 1984-05-22 | — | — | US | disclosed |