Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 5/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.31 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.30 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL11091539 | 0.97 | MEN1 (0.50) | MEN1CYP2C9KMT2AGAARECQL | |
| SCHEMBL3134616 | 0.87 | MEN1 (0.38) | MEN1CYP2C9KMT2AGAAAKR1C1 | |
| SCHEMBL4322724 | 0.83 | AKR1C1 (0.38) | MEN1CYP2C9KMT2AGAAAKR1C1 | |
| SCHEMBL1313846 | 0.83 | AKR1C1 (0.42) | GAAAKR1C1 | |
| SCHEMBL11098473 | 0.83 | MEN1 (0.34) | MEN1CYP2C9KMT2AHSD11B1 | |
| SCHEMBL11074308 | 0.83 | KMT2A (0.34) | MEN1CYP2C9KMT2AOPRM1HSD11B1 | |
| SCHEMBL11089638 | 0.83 | HSD11B1 (0.40) | MEN1CYP2C9KMT2AHSD11B1 | |
| SCHEMBL11093392 | 0.83 | KMT2A (0.34) | MEN1CYP2C9KMT2AOPRM1HSD11B1 | |
| SCHEMBL26916818 | 0.81 | AKR1C1 (0.41) | MEN1KMT2AGAAAKR1C1OPRM1 | |
| SCHEMBL11095896 | 0.81 | KCNA3 (0.41) | MEN1CYP2C9KMT2AALDH1A1KCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4447454-A | Analgetic compounds, compositions and process of treatment | THE UPJOHN COMPANY (US) | 1984-05-08 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4113866-A | ANALGETIC COMPOUNDS, COMPOSITIONS AND PROCESS OF TREATMENT | THE UPJOHN COMPANY (US) | 1978-09-12 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |