Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.71 |
| ▸ | MEN1 | O00255 | 8/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11080652 | 1.00 | KMT2A (0.71) | KMT2AMEN1MAPTRAB9AKDM4E | |
| SCHEMBL11088366 | 0.95 | POLB (0.66) | KMT2AMEN1MAPTRAB9AKDM4E | |
| SCHEMBL11088364 | 0.95 | POLB (0.66) | KMT2AMEN1MAPTRAB9AKDM4E | |
| SCHEMBL25858986 | 0.93 | KMT2A (0.83) | KMT2AMEN1MAPTRAB9AKDM4E | |
| SCHEMBL11080441 | 0.91 | KMT2A (0.70) | KMT2AMEN1MAPTRAB9AKDM4E | |
| SCHEMBL11080439 | 0.91 | KMT2A (0.70) | KMT2AMEN1MAPTRAB9AKDM4E | |
| SCHEMBL11080420 | 0.90 | KMT2A (0.86) | KMT2AMEN1MAPTRAB9AKDM4E | |
| SCHEMBL11080417 | 0.90 | KMT2A (0.86) | KMT2AMEN1MAPTRAB9AKDM4E | |
| SCHEMBL11089189 | 0.89 | KMT2A (0.65) | KMT2AMEN1MAPTRAB9AKDM4E | |
| SCHEMBL11089193 | 0.89 | KMT2A (0.65) | KMT2AMEN1MAPTRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4428952-A | Substituted pyrrolo[2,1-b]quinazolines and pyrido[2,1-b]quinazolines useful for the treatment of or the prevention of gastrointestinal ulcers | FARMITALIA CARLO ERBA S.P.A. (IT) | 1984-01-31 | — | — | US | disclosed |