Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.31 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL11084156 | 0.93 | MEN1 (0.40) | NR1I2TDP1KMT2AMEN1ALDH1A1 | |
| Succinic Acid SCHEMBL11087257 | 0.90 | TP53 (0.36) | NR1I2TDP1KMT2AMEN1HIF1A | |
| Succinic Acid SCHEMBL11080956 | 0.86 | TP53 (0.36) | NR1I2TDP1HIF1AALOX15TSHR | |
| Hydrochloric Acid SCHEMBL11085775 | 0.83 | MAPK1 (0.34) | TDP1KMT2ATP53ALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL11081116 | 0.78 | ESR1 (0.37) | NR1I2TDP1KMT2ATP53ALDH1A1 | |
| SCHEMBL11564908 | 0.77 | HDAC3 (0.35) | TDP1KMT2AMEN1TSHRCYP2C19 | |
| SCHEMBL11060077 | 0.76 | CACNA1C (0.39) | NR1I2TDP1KMT2AMEN1HIF1A | |
| SCHEMBL11054316 | 0.76 | TP53 (0.37) | NR1I2TDP1KMT2AMEN1TP53 | |
| Hydrochloric Acid SCHEMBL11088274 | 0.76 | GRIN2D (0.36) | TDP1KMT2AMEN1TSHRCYP2C19 | |
| Hydrochloric Acid SCHEMBL11053233 | 0.75 | CACNA1C (0.38) | NR1I2TDP1HIF1AALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4058557-A | Amidinoureas | WILLIAM H. RORER, INC. (US) | 1977-11-15 | — | — | US | claimed |
| US-4440949-A | Amidinoureas | WILLIAM H. RORER, INC. (US) | 1984-04-03 | — | — | US | disclosed |
| US-4242339-A | PHENYL-3-ALKOXYAMIDINOUREAS AND SALTS | WILLIAM H. RORER, INC. (US) | 1980-12-30 | — | — | US | disclosed |
| US-4242340-A | PHENYL-3-ALKOXYAMIDINOUREAS AND SALTS | WILLIAM H. RORER, INC. (US) | 1980-12-30 | — | — | US | disclosed |
| US-4242338-A | PHENYLCARBAMOYLAMIDINOUREA AND SALTS | WILLIAM H. RORER, INC. (US) | 1980-12-30 | — | — | US | disclosed |
| US-4242337-A | PHENYL-3-ALKOXYAMIDINOUREA AND SALTS | WILLIAM H. RORER, INC. (US) | 1980-12-30 | — | — | US | disclosed |
| US-4218450-A | Method for treatment of gastrointestinal spasmodic disease conditions or symptoms in mammals | WILLIAM H. RORER, INC. (US) | 1980-08-19 | — | — | US | disclosed |
| US-4169155-A | AMIDINOUREAS | WILLIAM H. RORER, INC. (US) | 1979-09-25 | — | — | US | disclosed |
| US-4115647-A | ANTISECRETORY, ANTISPASMODIC, ANTIULCEROGENIC, ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1978-09-19 | — | — | US | disclosed |