SCHEMBL11060077

SCHEMBL11060077

CCc1cccc(CC)c1N(C(=N)N)C(=O)NC

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 1/20 0.39
SCN5A Q14524 1/20 0.39
TP53 P04637 2/20 0.36
GABRA1 P14867 1/20 0.36
GABRB2 P47870 1/20 0.36
ALDH1A1 P00352 3/20 0.36
TDP1 Q9NUW8 3/20 0.36
CYP3A4 P08684 1/20 0.36
ALOX15 P16050 1/20 0.34
TSHR P16473 1/20 0.34
CYP2C19 P33261 1/20 0.34
HIF1A Q16665 1/20 0.34
NR1I2 O75469 1/20 0.33
HSD17B10 Q99714 1/20 0.33
GRIN2D O15399 1/20 0.33
GRIN3B O60391 1/20 0.33
GRIN1 Q05586 1/20 0.33
GRIN2A Q12879 1/20 0.33
GRIN2B Q13224 1/20 0.33
GRIN2C Q14957 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11053233 0.98 CACNA1C (0.38) CACNA1CSCN5ATP53GABRA1GABRB2
SCHEMBL10615590 0.94 ALDH1A1 (0.41) CACNA1CSCN5ATP53ALDH1A1TDP1
SCHEMBL10613030 0.90 ALDH1A1 (0.38) CACNA1CSCN5ATP53GABRA1GABRB2
SCHEMBL10614640 0.90 TP53 (0.35) CACNA1CSCN5ATP53ALDH1A1TDP1
SCHEMBL11057149 0.86 CACNA1C (0.38) CACNA1CSCN5ATP53GABRA1GABRB2
SCHEMBL10613079 0.85 CYP3A4 (0.34) CACNA1CSCN5ATP53ALDH1A1TDP1
SCHEMBL11060003 0.84 GRIN2D (0.35) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL10612763 0.84 PLAU (0.35) SCN5AALDH1A1TDP1CYP3A4HSD17B10
SCHEMBL11054316 0.84 TP53 (0.37) CACNA1CSCN5ATP53GABRA1GABRB2
SCHEMBL11053228 0.84 PTGES (0.36) CACNA1CSCN5ATP53GABRA1GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4338441-A CYCLIZATION OF AMIDINOUREA OR AMIDINOTHIOUREA WITH ACTIVE METHYLIDENE COMPOUND WILLIAM H. RORER, INC. (US) 1982-07-06 US claimed
US-4178387-A ADMINISTERING AMIDINOUREAS WILLIAM H. RORER, INC. (US) 1979-12-11 US claimed
US-4452980-A DIARRHEA WILLIAM H. RORER, INC. (US) 1984-06-05 US disclosed
US-4338441-A CYCLIZATION OF AMIDINOUREA OR AMIDINOTHIOUREA WITH ACTIVE METHYLIDENE COMPOUND WILLIAM H. RORER, INC. (US) 1982-07-06 US disclosed
US-4298608-A LOCAL ANESTHETICS WILLIAM H. RORER, INC. (US) 1981-11-03 US disclosed
EP-0026221-A4 DYSMENORRHEA TREATMENT. RORER INC WILLIAM H (US) 1981-08-27 EP disclosed
US-4279928-A Method of lowering blood pressure WILLIAM H. RORER, INC. (US) 1981-07-21 US disclosed
EP-0026221-A1 DYSMENORRHEA TREATMENT WILLIAM H. RORER, INC. (US) 1981-04-08 EP disclosed
US-4246409-A ANTIDIARRHEAL AGENTS WILLIAM H. RORER, INC. (US) 1981-01-20 US disclosed
US-4241087-A AMIDINOUREAS WILLIAM H. RORER, INC. (US) 1980-12-23 US disclosed
WO-1980002110-A1 DYSMENORRHEA TREATMENT RORER INC WILLIAM H (US) 1980-10-16 WO disclosed
US-4225315-A Triazinones from amidinoureas WILLIAM H. RORER, INC. (US) 1980-09-30 US disclosed
US-4203983-A GASTROINTESTINAL DISORDERS WILLIAM H. RORER, INC. (US) 1980-05-20 US disclosed
US-4203985-A Antidiarrheal triazinones WILLIAM H. RORER, INC. (US) 1980-05-20 US disclosed
US-4203984-A Antisecretory triazinones WILLIAM H. RORER, INC. (US) 1980-05-20 US disclosed
US-4198408-A 1,4-DISUBSTITUTED-1,2-DIHYDRO-1,3,5-TRIHZIN-2-ONES WILLIAM H. RORER, INC. (US) 1980-04-15 US disclosed
US-4198409-A ANTIDIARRHEAL WILLIAM H. RORER, INC. (US) 1980-04-15 US disclosed
US-4147804-A ANTIARRHYTHMIA AGENTS WILLIAM H. RORER, INC. (US) 1979-04-03 US disclosed