Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 5/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 7/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11080965 | 1.00 | HRH2 (0.43) | HRH2SCN5ASCN2ARAB9ANPC1 | |
| SCHEMBL9867137 | 0.96 | HRH2 (0.49) | HRH2SCN5ASCN2ARAB9ANPC1 | |
| SCHEMBL9865344 | 0.96 | HRH2 (0.49) | HRH2SCN5ASCN2ARAB9ANPC1 | |
| SCHEMBL11080978 | 0.96 | HRH2 (0.47) | HRH2SCN5ASCN2ARAB9ANPC1 | |
| SCHEMBL9867162 | 0.93 | HRH2 (0.52) | HRH2SCN5ASCN2ARAB9ANPC1 | |
| SCHEMBL9866817 | 0.93 | HRH2 (0.52) | HRH2SCN5ASCN2ARAB9ANPC1 | |
| SCHEMBL9866822 | 0.93 | HRH2 (0.52) | HRH2SCN5ASCN2ARAB9ANPC1 | |
| SCHEMBL9865348 | 0.92 | HRH2 (0.53) | HRH2SCN5ASCN2ARAB9ANPC1 | |
| SCHEMBL9865894 | 0.91 | SCN5A (0.45) | HRH2SCN5ASCN2ARAB9ANPC1 | |
| SCHEMBL9865887 | 0.91 | SCN5A (0.45) | HRH2SCN5ASCN2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4443375-A | Tetrahydroimidazo(3,4-c)-1,3-diazocine intermediates for production of guanidines | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-04-17 | — | — | US | disclosed |
| US-4375435-A | 3-,4-Dihydroimidazo (3,4-c)-1,3-pyrimidines and 4,5-dihydroimidazo (3,4-c)-1,3-diazepines | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-03-01 | — | — | US | disclosed |
| EP-0041359-A1 | Process for the preparation of heterocyclylalkyl guanidines; intermediates and their preparation | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-12-09 | — | — | EP | disclosed |