Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 6/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 6/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MLYCD | O95822 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866822 | 1.00 | HRH2 (0.52) | HRH2NPC1RAB9ASCN5ASCN2A | |
| SCHEMBL9866817 | 1.00 | HRH2 (0.52) | HRH2NPC1RAB9ASCN5ASCN2A | |
| SCHEMBL9867137 | 0.97 | HRH2 (0.49) | HRH2NPC1RAB9ASCN5ASCN2A | |
| SCHEMBL9865348 | 0.97 | HRH2 (0.53) | HRH2NPC1RAB9ASCN5ASCN2A | |
| SCHEMBL9865344 | 0.97 | HRH2 (0.49) | HRH2NPC1RAB9ASCN5ASCN2A | |
| SCHEMBL11080965 | 0.93 | HRH2 (0.43) | HRH2NPC1RAB9ASCN5ASCN2A | |
| SCHEMBL11080978 | 0.93 | HRH2 (0.47) | HRH2NPC1RAB9ASCN5ASCN2A | |
| SCHEMBL11080973 | 0.93 | HRH2 (0.43) | HRH2NPC1RAB9ASCN5ASCN2A | |
| SCHEMBL10875814 | 0.92 | HRH2 (0.49) | HRH2NPC1RAB9AHRH4EPHX2 | |
| SCHEMBL10875704 | 0.89 | PTAFR (0.51) | HRH2SCN5ASCN2AHRH4EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |