Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11080477 | 1.00 | MAPT (0.34) | MAPTHTTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL11081045 | 1.00 | MAPT (0.34) | MAPTHTTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL15894857 | 1.00 | MAPT (0.34) | MAPTHTTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL15894856 | 0.82 | MEN1 (0.33) | ALDH1A1SMN1; SMN2HSD17B10KDM4ECYP2C19 | |
| SCHEMBL15894858 | 0.79 | CYP3A4 (0.41) | MAPTHTTALDH1A1TP53GAA | |
| SCHEMBL17232288 | 0.77 | NR1I2 (0.39) | ALDH1A1 | |
| SCHEMBL17232363 | 0.76 | NR1I2 (0.36) | — | |
| SCHEMBL11068690 | 0.76 | HTT (0.37) | MAPTHTTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL9728987 | 0.76 | HTT (0.37) | MAPTHTTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL15894829 | 0.76 | HTT (0.37) | MAPTHTTALDH1A1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0013787-B1 | OCTAHYDRO PYRAZOLO (3,4-G)QUINOLINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 1984-05-02 | — | — | EP | disclosed |
| EP-0050881-B1 | OCTAHYDRO QUINOLINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1984-04-25 | — | — | EP | disclosed |
| US-4367231-A | PARKINSON*S SYNDROME | ELI LILLY AND COMPANY (US) | 1983-01-04 | — | — | US | disclosed |
| EP-0050881-A1 | Octahydro quinoline derivatives | ELI LILLY AND COMPANY (US) | 1982-05-05 | — | — | EP | disclosed |
| US-4311844-A | Octahydro-2H-pyrrolo[3,4,-g]quinolines | ELI LILLY AND COMPANY (US) | 1982-01-19 | — | — | US | disclosed |
| US-4282362-A | TREATING PARKINSON'S DISEASE, INHIBITORS OF PRE ACTIN SECRETION, DOPAMINE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1981-08-04 | — | — | US | disclosed |
| US-4235909-A | DOPAMINE ANTAGONISTS, IN THE TREATMENT OF PARKINSON'S DISEASE | ELI LILLY AND COMPANY (US) | 1980-11-25 | — | — | US | disclosed |
| US-4230861-A | DOPAMINE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1980-10-28 | — | — | US | disclosed |
| EP-0013788-A1 | Octahydro-2H-pyrrolo(3,4-g)quinolines, process for their preparation and pharmaceutical compositions containing them | ELI LILLY AND COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |
| EP-0013787-A1 | Octahydro pyrazolo (3,4-g)quinolines, process for their preparation and pharmaceutical compositions containing them | ELI LILLY AND COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |
| US-4198415-A | Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines | ELI LILLY AND COMPANY (US) | 1980-04-15 | — | — | US | disclosed |