Sugi Predict

Sugi Predict / Compounds / SCHEMBL1108222

SCHEMBL1108222

SCHEMBL1108222

CCN(CC)CCOc1ccc2cc1COC/C=C/COCc1cccc(c1)-c1ccnc(n1)N2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ JAK2 O60674 18/20 1.00
▸ TYK2 P29597 11/20 1.00
▸ FLT3 P36888 10/20 1.00
▸ JAK3 P52333 9/20 1.00
▸ CCNA2 P20248 8/20 1.00
▸ JAK1 P23458 8/20 1.00
▸ CDK2 P24941 8/20 1.00
▸ CCNA1 P78396 8/20 1.00
▸ CYP3A4 P08684 3/20 1.00
▸ GAK O14976 1/20 0.72
▸ STK16 O75716 1/20 0.72
▸ STK10 O94804 1/20 0.72
▸ MAP4K4 O95819 1/20 0.72
▸ PRKCB P05771 1/20 0.72
▸ LCK P06239 1/20 0.72
▸ CSF1R P07333 1/20 0.72
▸ PDGFRB P09619 1/20 0.72
▸ CYP2D6 P10635 1/20 0.72
▸ NQO2 P16083 1/20 0.72
▸ FER P16591 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19605452 0.91 JAK2 (0.84) JAK2TYK2FLT3JAK3CCNA2
SCHEMBL1108233 0.91 JAK2 (0.83) JAK2TYK2FLT3JAK3CCNA2
SCHEMBL1108235 0.89 JAK2 (0.79) JAK2TYK2FLT3JAK3CCNA2
SCHEMBL1108227 0.88 JAK2 (0.78) JAK2TYK2FLT3JAK3CCNA2
SCHEMBL19605444 0.88 JAK2 (1.00) JAK2TYK2FLT3JAK3CCNA2
SCHEMBL1108216 0.85 JAK2 (1.00) JAK2TYK2FLT3JAK3CCNA2
SCHEMBL1108243 0.85 JAK2 (0.74) JAK2TYK2FLT3JAK3CCNA2
SCHEMBL20322432 0.85 JAK2 (0.89) JAK2TYK2FLT3JAK3CCNA2
SCHEMBL14538460 0.84 JAK2 (0.73) JAK2TYK2FLT3JAK3CCNA2
Pacritinib SCHEMBL1108221 0.84 JAK2 (1.00) JAK2TYK2FLT3JAK3CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11135227-B2 Oxygen linked pyrimidine derivatives CTI BIOPHARMA CORP. (US) 2021-10-05 — — US disclosed
EP-3854402-A1 TREATMENT OR PREVENTION OF TRANSPLANT REJECTION CTI Biopharma Corp. (US) 2021-07-28 — — EP disclosed
US-20210069199-A1 METHODS OF TREATING TRANSPLANT REJECTION SOBI, INC. 2021-03-11 — — US disclosed
US-20200071339-A1 OXYGEN LINKED PYRIMIDINE DERIVATIVES CTI BIOPHARMA CORP. (US) 2020-03-05 — — US disclosed
US-20170112846-A1 OXYGEN LINKED PYRIMIDINE DERIVATIVES CTI BIOPHARMA CORP. (US) 2017-04-27 — — US disclosed
US-20170112846-A1 OXYGEN LINKED PYRIMIDINE DERIVATIVES CTI BIOPHARMA CORP. (US) 2017-04-27 — — US disclosed
US-9573964-B2 Oxygen linked pyrimidine derivatives CTI BIOPHARMA CORP. (US) 2017-02-21 — — US disclosed
US-9573964-B2 Oxygen linked pyrimidine derivatives CTI BIOPHARMA CORP. (US) 2017-02-21 — — US disclosed
EP-1951729-B1 OXYGEN LINKED PYRIMIDINE DERIVATIVES CELL THERAPEUTICS INC (US) 2014-06-25 — — EP disclosed
US-20130172338-A1 OXYGEN LINKED PYRIMIDINE DERIVATIVES CELL THERAPEUTICS, INC. (US) 2013-07-04 — — US disclosed
US-20130172338-A1 OXYGEN LINKED PYRIMIDINE DERIVATIVES CELL THERAPEUTICS, INC. (US) 2013-07-04 — — US disclosed
US-8415338-B2 Oxygen linked pyrimidine derivatives CELL THERAPEUTICS, INC. (US) 2013-04-09 — — US disclosed
US-8415338-B2 Oxygen linked pyrimidine derivatives CELL THERAPEUTICS, INC. (US) 2013-04-09 — — US disclosed
US-20120196855-A1 OXYGEN LINKED PYRIMIDINE DERIVATIVES S*BIO PTE LTD. (SG) 2012-08-02 — — US disclosed
US-20120196855-A1 OXYGEN LINKED PYRIMIDINE DERIVATIVES S*BIO PTE LTD. (SG) 2012-08-02 — — US disclosed
US-8153632-B2 Oxygen linked pyrimidine derivatives S*BIO PTE LTD. (SG) 2012-04-10 — — US disclosed
US-8153632-B2 Oxygen linked pyrimidine derivatives S*BIO PTE LTD. (SG) 2012-04-10 — — US disclosed
US-20090075999-A1 OXYGEN LINKED PYRIMIDINE DERIVATIVES S*BIO PTE LTD. (SG) 2009-03-19 — — US disclosed
US-20090075999-A1 OXYGEN LINKED PYRIMIDINE DERIVATIVES S*BIO PTE LTD. (SG) 2009-03-19 — — US disclosed
WO-2007058627-A1 OXYGEN LINKED PYRIMIDINE DERIVATIVES S*BIO PTE LTD (SG) 2007-05-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210069199-A1 METHODS OF TREATING TRANSPLANT REJECTION JAK1, JAK2, JAK3 JAK2 2/4885TYK2 34/4885FLT3 50/4885
US-20090075999-A1 OXYGEN LINKED PYRIMIDINE DERIVATIVES DPYD, TK2, TK1 JAK2 468/4885TYK2 960/4885FLT3 645/4885
US-20130172338-A1 OXYGEN LINKED PYRIMIDINE DERIVATIVES DPYD, TK2, TK1 JAK2 468/4885TYK2 960/4885FLT3 645/4885
US-20170112846-A1 OXYGEN LINKED PYRIMIDINE DERIVATIVES DPYD, TK2, TK1 JAK2 468/4885TYK2 960/4885FLT3 645/4885
US-20120196855-A1 OXYGEN LINKED PYRIMIDINE DERIVATIVES DPYD, TK2, TK1 JAK2 468/4885TYK2 960/4885FLT3 645/4885
US-11135227-B2 Oxygen linked pyrimidine derivatives DPYD, TK2, TK1 JAK2 468/4885TYK2 960/4885FLT3 645/4885
US-20200071339-A1 OXYGEN LINKED PYRIMIDINE DERIVATIVES DPYD, TK2, TK1 JAK2 468/4885TYK2 960/4885FLT3 645/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.