Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.41 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11080131 | 0.78 | PTGS2 (0.52) | PTGS2PTGS1MAPK14KDM4EMT-CO1 | |
| SCHEMBL11183966 | 0.78 | PTGS2 (0.59) | PTGS2PTGS1MAPK14KDM4EMT-CO1 | |
| SCHEMBL11189076 | 0.77 | PTGS2 (0.54) | PTGS2PTGS1MAPK14KDM4EMT-CO1 | |
| SCHEMBL11188282 | 0.75 | PTGS2 (0.56) | PTGS2PTGS1MAPK14KDM4EMT-CO1 | |
| SCHEMBL11220738 | 0.74 | PTGS2 (0.52) | PTGS2PTGS1MAPK14KDM4EMT-CO1 | |
| SCHEMBL8985334 | 0.73 | PTGS2 (0.50) | PTGS2PTGS1MAPK14KDM4EMT-CO1 | |
| SCHEMBL11191447 | 0.72 | PTGS2 (0.50) | PTGS2PTGS1MAPK14KDM4EMT-CO1 | |
| SCHEMBL11087506 | 0.72 | PTGS1 (0.51) | PTGS2PTGS1MAPK14KDM4EMT-CO1 | |
| SCHEMBL11182987 | 0.72 | PTGS2 (0.52) | PTGS2PTGS1MAPK14KDM4EMT-CO1 | |
| SCHEMBL11178747 | 0.71 | PTGS2 (0.49) | PTGS2PTGS1MAPK14KDM4EMT-CO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4427693-A | ANTIARTHRITIC AGENTS; ANALGESICS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-01-24 | — | — | US | disclosed |
| EP-0055471-A1 | Antiinflammatory 4,5-diaryl-alpha,alpha-bis(polyhalomethyl)-2-thiophenemethanamines | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-07-07 | — | — | EP | disclosed |