Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.53 |
| ▸ | MEN1 | O00255 | 8/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | NME2 | P22392 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11083339 | 1.00 | RAB9A (0.55) | RAB9ANPC1KMT2AMEN1ALOX5 | |
| SCHEMBL11088016 | 0.91 | KMT2A (0.59) | RAB9ANPC1KMT2AMEN1ALOX5 | |
| SCHEMBL11088020 | 0.91 | KMT2A (0.59) | RAB9ANPC1KMT2AMEN1ALOX5 | |
| SCHEMBL11081499 | 0.91 | NPC1 (0.57) | RAB9ANPC1KMT2AMEN1ALOX5 | |
| SCHEMBL11081502 | 0.91 | NPC1 (0.57) | RAB9ANPC1KMT2AMEN1ALOX5 | |
| SCHEMBL11085206 | 0.90 | MEN1 (0.66) | RAB9ANPC1KMT2AMEN1ALOX5 | |
| SCHEMBL11085210 | 0.90 | MEN1 (0.66) | RAB9ANPC1KMT2AMEN1ALOX5 | |
| SCHEMBL11090209 | 0.89 | CCR3 (0.61) | RAB9ANPC1KMT2AMEN1ALOX5 | |
| SCHEMBL11090215 | 0.89 | CCR3 (0.61) | RAB9ANPC1KMT2AMEN1ALOX5 | |
| SCHEMBL11090414 | 0.88 | RAB9A (0.55) | RAB9ANPC1KMT2AMEN1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4428952-A | Substituted pyrrolo[2,1-b]quinazolines and pyrido[2,1-b]quinazolines useful for the treatment of or the prevention of gastrointestinal ulcers | FARMITALIA CARLO ERBA S.P.A. (IT) | 1984-01-31 | — | — | US | disclosed |